Effects of subacute treatment with toluene on cerebrocortical α- and β-adrenergic receptors in the rat. Evidence for an increased number and a reduced affinity of β-adrenergic receptors |
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Authors: | K. FUXE,M. MARTIRE,G. VON EULER,L. F. AGNATI,T. HANSSON,K. ANDERSSON,J.- GUSTAFSSON,A. HARFSTRAND |
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Affiliation: | K. FUXE,M. MARTIRE,G. VON EULER,L. F. AGNATI,T. HANSSON,K. ANDERSSON,J.-Å GUSTAFSSON,A. HARFSTRAND |
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Abstract: | Subacute treatment with toluene (80–1500 p.p.m.) produces a dose-dependent reduction of affinity and increase in density of the β-adrenergic antagonist [3H]dihydroalprenolol binding sites in the frontoparietal cortex of the male rat, while the binding characteristics of a,-adrenergic ([3H]WB 4101) and α2-adrenergic ([3H]p-aminoclonidine) binding sites in the same region is unaffected by this treatment as evaluated in vitro. Therefore, it is suggested that the cortical β-adrenergic receptors are particularly vulnerable to the action of toluene in vivo. It is speculated that as a result cortical β-adrenergic neurotransmission may be altered following exposure to low concentrations of toluene, possibly related to the physico-chemical properties of toluene, leading to changes in membrane fluidity. |
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Keywords: | β - α 1-and α 2-adrenergic receptors p-[3H]aminoclonidine [3H]dihydroal-prenolol frontoparietal cortex rat toluene [3H]WB 4101. |
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