| Fas FasL在BOWen病和鳞状细胞癌中的表达及意义 |
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| 引用本文： | 耿松梅,刘恩让,张磐谏,谭升顺. Fas FasL在BOWen病和鳞状细胞癌中的表达及意义[J]. 中国皮肤性病学杂志, 2000, 14(1): 10-12 |
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| 作者姓名： | 耿松梅 刘恩让 张磐谏 谭升顺 |
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| 作者单位： | 西安医科大学第二临床医学院皮肤科 710004 |
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| 摘 要： | 目的探讨由Ｆａｓ和ＦａｓＬ倡导的凋亡在Ｂｏｗｅｎ病和鳞状细胞癌（ＳＣＣ）局部免疫反应中的作用。方法 采用免疫组化对Ｂｏｗｅｎ病、ＳＣＣ不同恶性度分级的皮损蜡块组织中Ｆａｓ、ＦａｓＬ表达情况进行检测。结果 Ｆａｓ、ＦａｓＬ在Ｂｏｗｅｎ病和ＳＣＣ上均表达，但随肿瘤恶性程度升高Ｆａｓ表达逐渐减弱，而ＦａｓＬ表达逐渐增强。结论 由Ｆａｓ系统介导的凋亡所引发的异常免疫杀伤作用可能参与某些表皮肿瘤局部免疫逃避
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| 关 键 词： | Fas FasL Bowen病 鳞状细胞癌 皮肤肿瘤 |
| 修稿时间： | 1998-10-15 |
Expression of Fas and Fas Ligand in Bowen's Disease and Squamous Cell Carcinoma. |
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| Geng Songmei,Liu Enrang,Zheng Panjian,et al.. Expression of Fas and Fas Ligand in Bowen's Disease and Squamous Cell Carcinoma.[J]. The Chinese Journal of Dermatovenereology, 2000, 14(1): 10-12 |
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| Authors: | Geng Songmei Liu Enrang Zheng Panjian et al. |
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| Affiliation: | Geng Songmei,Liu Enrang,Zheng Panjian,et al.Department of dermatology,The Second Hospital Affiliated of Xi'an Medical University Xi'an 710004. |
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| Abstract: | Objective To study the function of apoptosis mediated by Fas and Fas ligand in Bowen's disease and sqamous cell carcoma(SCC).Method The immunohistochemistry was empolyed to show the expression of Fas and Fas ligand in Bowen's Disease and SCC.Results The positive rates of Fas and Fas ligand in Bowen's Disease and SCC were both 100%,the intense of expressions of Fas was downregulated and that of Fas ligand was upregulated along with the increasing malignant degree of tumors.Conclusions Expression of Fas and Fas ligand are related to degree of epidermal tumors,and apoptosis mediated by Fas and Fas ligand may be one cause responsible to epidermal tumor's local immune evasion. |
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| Keywords: | Fas Fas Ligand Apoptosis Bowen's Disease Squamous Cell cacinoma |
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