影响小梁切除术联合术中应用丝裂霉素C治疗新生血管性青光眼手术效果的因素

目的：分析小梁切除术联合术中应用丝裂霉素 C 治疗新生血管性青光眼手术效果的影响因素。
　　方法：收集2013-01/2015-08我院眼科行小梁切除术联合术中应用丝裂霉素 C 治疗新生血管性青光眼50例50眼，单因素变量和多因素变量分析影响小梁切除术联合术中应用丝裂霉素 C 治疗新生血管性青光眼手术术后效果的因素。
　　结果：单因素变量分析结果显示，患者年龄<50岁、术前眼压≥45mmHg 及术后发生前房出血是治疗失败的危险因素(P<0.05)，而性别、增殖型糖尿病视网膜病变、既往白内障手术史及术前全视网膜光凝史不是治疗失败的危险因素(P>0.05)。多因素变量分析，患者年龄<50岁及术后发生前房出血是治疗失败的危险因素(P<0.05)，而术前眼压≥45mmHg 不是治疗失败的危险因素(P>0.05)。结论：对于年龄<50岁的新生血管性青光眼患者，应慎重选择手术治疗方法，对于高危患者，应该加强监护并及时采取干预措施，有助于改善患者预后。

Effect factors of trabeculectomy with intraoperative application of mitomycin C for neovascular glaucoma

AIM: To analyze the effect factors of trabeculectomy combined with intraoperative application of mitomycin C in the treatment of neovascular glaucoma.
METHODS: Fifty patients (50 eyes) with neovascular glaucoma collected from January 2013 to August 2015 in our hospital were treated by trabeculectomy combined with intraoperative application of mitomycin C. Single factor and multi factor variables analysis were used for effect factors of trabeculectomy combined with intraoperative application of mitomycin C in the treatment of neovascular glaucoma.
RESULTS: By results of single factor variable analysis,< 50 years old, preoperative intraocular pressure ( IOP) was ≥45mmHg and postoperative occurrence of anterior chamber hemorrhage were risk factors for treatment failure ( P < 0. 05 ), and gender, proliferative diabetic retinopathy and previous cataract surgery and prior photocoagulation were not the risk factors for failure (P>0. 05 ). By multivariate analysis, < 50 years old and postoperative occurrence of anterior chamber hemorrhage were risk factors for treatment failure ( P < 0. 05 ), and preoperative IOP≥45mmHg was not a risk factor (P>0.05). CONCLUSION: For patients < 50 years old with neovascular glaucoma, should be careful on the selection of surgical treatment. For high- risk patients, we should strengthen the monitoring and give timely intervention, which are helpful to improve the prognosis.