甲泼尼龙冲击联合曲安奈德眶周注射治疗弥漫型眼眶炎性假瘤

目的：观察甲泼尼龙冲击联合曲安奈德眶周注射治疗弥漫型眼眶假瘤的疗效。
　　方法：选择弥漫型眼眶炎性假瘤15例19眼,应用甲泼尼龙静脉冲击治疗,给予甲泼尼龙琥珀酸钠0.5g 加入250mL 生理盐水中静脉滴注,1次/ d×3d,再以0.5g 1次/ wk×3wk,随后以0.25g 1次/ wk×6wk,总疗程10wk,甲泼尼龙总剂量4.5g。同时,从第1次静脉滴注甲泼尼龙冲击治疗开始,应用曲安奈德注射液40mg/ mL 行第1次患眼眶周注射,每3wk 1次,共2~4次。
　　结果：完全治愈7例8眼,部分治愈8例11眼,无效0例。在治疗观察中无复发加重表现。
　　结论：甲泼尼龙冲击联合曲安奈德眶周注射治疗弥漫型眼眶假瘤方法可行、疗效明显、副作用少。

Clinical observation of methylprednisolone combined with peri-orbital injection of triamcinolone acetonide for diffuse-type orbital inflammatory pseudotumor

AIM: To observe the effect of intravenous methylprednisolone combined with peri-orbital injection of triamcinolone acetonide for diffuse-type orbital inflammatory pseudotumor.

METHODS: Diffuse-type orbital inflammatory pseudotumor in 15 cases(19 eyes)were treated. Intravenous implosive methylprednisolone therapy(0.5g/d)was used in the first 3d, and 0.5g once a week in the following 3wk, ended by 0.25g once a week in the last 6wk, which meant the total dose was 4.5g and the whole course lasted for 10wk. At the same time, peri-orbital injection of triamcinolone acetonide(40mg)was performed once in every 3wk, totally 2-4 times.

RESULTS: Eight eyes from 7 cases were completely cured, 11 eyes from 8 cases were partly cured. No recurrence and severe complications were observed in the treatment duration.

CONCLUSION: Intravenous methylprednisolone combined with peri-orbital injection of triamcinolone acetonide is effective, safe and feasible in treatment of diffuse type orbital pseudotumor with less complications.