急性冠脉综合征介入治疗后脑钠肽水平与心血管事件关系探讨

目的:探讨急性冠状动脉综合征(ACS)患者行经皮冠状动脉介入治疗(PCI)术后48h血浆脑钠肽(BNP)水平变化与近、远期心血管事件关系。方法:对92例ACS患者常规进行术前和术后治疗并规范化行PCI术,术后48h行BNP测定,A组血浆BNP水平>80pg/ml,B组血浆BNP水平<80pg/ml;观察两组住院期间及术后6个月心血管事件发生率。结果:A组住院期间心血管事件发生率明显高于B组(P<0.01);但两组术后6个月心血管事件发生率无明显差异(P>0.05)。结论:ACS患者行PCI术,术后48hBNP浓度仅能预测近期预后而对远期预后无明显的预测作用。

Relationship between brain natriuretic peptide levels in and cardiovascular eventspatients with acute coronary syndrome after percutaneous coronary intervention

Objective： To analyze the relationship between variation of brain natriuretic peptide （BNP）and short and long-term cardiovascular events in patients with acute coronary syndrome （ACS） at 48 hours after percutaneous coronary intervention（PCI） . Methods： Totally 92 patients with AGS were given conventional preoperative and postoperative medication and standardized PC1. Plasma levels of BNP were measured at 48 hours after operations. All patients were divided into two groups according to the level of BNP： A group （BNP 〉 80pg/ml） and B group （BNP 〈 80pg/ml）. The incidence of cardiovascular events during hospitalization and at 6 months after PCI was analyzed. Results： Compared with B group, the incidence of cardiovascular events in A group was significantly higher during hospitalization（P〈0. 01）,but there was no difference at 6 months after PCI（P〉0. 05）. Conclusion： BNP concentration in patients with ACS at 48 hours after PCI can only predict short-term prognosis, but can not predict the long-term prognosis.