| 重庆麻鸭乙肝动物模型的建立及应用——21种中药抗鸭乙型肝炎病毒初筛研究 |
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| 引用本文： | 陈压西,郭树华,张定凤,陈学华.重庆麻鸭乙肝动物模型的建立及应用——21种中药抗鸭乙型肝炎病毒初筛研究[J].中西医结合肝病杂志,1994(3). |
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| 作者姓名： | 陈压西 郭树华 张定凤 陈学华 |
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| 作者单位： | 重庆医科大学病毒性肝炎研究所 630010
(陈压西，郭树华，张定凤)，重庆医科大学病毒性肝炎研究所 630010(陈学华) |
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| 摘 要： | 采用斑点杂交法检测了重庆地区263份2～3月龄麻鸭血清中的DHBV DNA,用筛选出的阳性病毒血清经腹腔感染1～2日龄的血清DHBV DNA阴性雏鸭,并用该模型进行了21种中药抗乙肝病毒初(?)。结果表明:(1)重庆地区2～3日龄麻鸭DHBV自然感染率为25.48％.(2)经腹腔感染的1～2日龄雏鸭的血清DHBV DNA阳性率1周后为82.90％,并可持续至少2个月。(3)抗乙肝病毒中药初(?)发现用广西叶下珠、苦参治疗2周可使DHBV DNA滴度下降,其余的经体外实验认为有效的抗乙肝病毒中药,动物实验并未获证实。
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| 关 键 词： | 鸭乙型肝炎病毒 动物模型 叶下珠 苦参 |
Established Chongqing Spotted Duck Hepatitis B Animal Model for Screening the Antiviral Effect of 21 Kinds of Traditional Chinese Medicine |
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| Chen Yaxi,Guo Shuhua,Zhang Dinyfeng Institute for Viral Hepatitis,Chongqing Medical University.Established Chongqing Spotted Duck Hepatitis B Animal Model for Screening the Antiviral Effect of 21 Kinds of Traditional Chinese Medicine[J].Chinese Journal of Integrated Traditonal and Western Medicine on Liver Diseases,1994(3). |
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| Authors: | Chen Yaxi Guo Shuhua Zhang Dinyfeng Institute for Viral Hepatitis Chongqing Medical University |
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| Abstract: | Uninfected 1-2 day-old Chongqing ducklings were inoculated intraperioneally with serum containning DHBV to establish duck hepatitis B animal model. We used the model for screening 21 Kinds of tradional Chinese medicine. The following results were obstained: (1) The natural infected rate of 2-3month-old ducks is 25. 48%. (2) These ducklings inoculating with DHBV can produced a persistent infection over 2 month and infected rate was 82.90%. (3) The serum DHBV DNA was decreased after the treatment 2 weeks with Guangxi Phyllanthus, Ku Shen. No significant effect was observed in other drugs in the animal test. |
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| Keywords: | Duck Hepatitis B Virus Animal Model Phyllanthus |
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