| 重组人Elafin对肝脏缺血-再灌注损伤的保护作用 |
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| 引用本文： | 孙任任,张赢予,孙波,张馨木. 重组人Elafin对肝脏缺血-再灌注损伤的保护作用[J]. 中国药业, 2011, 20(5): 6-7 |
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| 作者姓名： | 孙任任 张赢予 孙波 张馨木 |
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| 作者单位： | 1. 吉林大学药学院,吉林,长春,130021
2. 吉林大学药学院,吉林,长春,130021;江苏大学附属人民医院心血管病研究所,江苏,镇江,212002 |
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| 摘 要： | 目的探讨重组人Elafin在大鼠肝脏缺血-再灌注损伤中的保护作用。方法将50只大鼠随机均分为5组,即正常对照组、肝脏缺血-再灌注损伤模型组以及Elafin低、中、高剂量组。对Elafin低、中、高剂量组给予不同浓度的重组人Elafin进行治疗,然后取血液及肝脏标本,检测血清中丙氨酸氨基转移酶(ALT)、天门冬酸氨基转移酶(AST)及乳酸脱氢酶(LDH)水平,测定肝组织中髓过氧化物酶(MPO)和一氧化氮(NO)含量,并观察肝脏的病理组织学改变。结果缺血-再灌注后大鼠肝组织损害较重,血清ALT和AST以及LDH水平明显升高(P<0.001),肝组织中MPO和NO含量明显升高(P<0.001);若手术前给予大鼠一定浓度的重组人Elafin,可使ALT,AST,LDH,MPO及NO水平明显降低(P<0.05)。结论重组人Elafin对肝脏缺血-再灌注损伤有一定的保护作用。
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| 关 键 词： | 肝缺血-再灌注损伤 重组人Elafin 丙氨酸氨基转移酶 天门冬酸氨基转移酶 乳酸脱氢酶 髓过氧化物酶 一氧化氮 |
Effect of Recombinant Human Elafin on Hepatic Ischemia-Reperfusion Injury in Rat |
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| Sun Renren,Zhang Yingyu,Sun Bo,Zhang Xinmu. Effect of Recombinant Human Elafin on Hepatic Ischemia-Reperfusion Injury in Rat[J]. China Pharmaceuticals, 2011, 20(5): 6-7 |
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| Authors: | Sun Renren Zhang Yingyu Sun Bo Zhang Xinmu |
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| Affiliation: | Sun Renren1,Zhang Yingyu1,2,Sun Bo1,Zhang Xinmu1(1.School of Pharmaceutical Sciences,Jilin University,Changchun,Jilin,China 130021,2.Research Institute of Cardiovascular Diseases,Affiliated Hospital,Jiangsu University,Zhenjiang,Jiangsu,China 212002) |
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| Abstract: | Objective To investigate the role of recombinant human Elafin in the pathogenesis of hepatic ischemia-reperfusion injury(HIRI).Methods All rats were divided into 5 groups randomly,sham-operation group,model group,Elafin treatment groups(high,middle and low doses),10 cases in each group.Elafin was given with high,middle and low doses in Elafin treatment groups.The rat model of HIRI was made.The contents of serum ALT,AST and LDH and liver MPO and NO were determined after the injection of Elafin.Meanwhile,the ... |
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| Keywords: | hepatic ischemia-reperfusion injury recombinant human Elafin ALT AST LDH MPO NO |
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