Liver cancer risk, coffee, and hepatitis C virus infection: a nested case-control study in Japan |
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| Authors: | Wakai K,Kurozawa Y,Shibata A,Fujita Y,Kotani K,Ogimoto I,Naito M,Nishio K,Suzuki H,Yoshimura T,Tamakoshi A JACC Study Group |
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| Affiliation: | Department of Preventive Medicine/Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. wakai@med.nagoya-u.ac.jp |
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| Abstract: | We examined hepatocellular carcinoma mortality in relation to coffee consumption and anti-hepatitis C virus (HCV) antibody seropositivity in a nested case-control study involving 96 cases. The multivariate-adjusted odds ratios (95% confidence interval) for daily coffee drinkers vs non-drinkers were 0.49 (0.25-0.96), 0.31 (0.11-0.85), and 0.75 (0.29-1.92) in all cases, in HCV-positive and in HCV-negative individuals, respectively. |
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| Keywords: | coffee hepatocellular carcinoma hepatitis C virus cohort study nested case–control study |
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