HIV感染者和AIDS患者T淋巴细胞亚群的变化及其临床意义

目的探讨衡阳地区HIV感染者和AIDS患者T淋巴细胞亚群的免疫病理改变情况及其临床意义。方法收集59例HIV感染者（HIV组）、50例AIDS患者（AIDS组）、31例健康体检人员（正常对照组）的抗凝血,用流式细胞仪单平台技术检测外周血T4及T8淋巴细胞。结果正常对照组、HIV组、AIDS组外周血T4细胞计数分别为（673±362,337±278）、（129±124）（个/μl）,组间比较,正常对照组明显高于HIV组和AIDS组（P〈0.01）;T8细胞计数分别为（478±243）、（940±844）、（707±636）（个/μl）,HIV组明显高于对照组（P〈0.05）;T4细胞与T8细胞比值（TH/S）分别为（1.49±0.90）、（0.39±0.38）、（0.18±0.17）,正常对照组明显高于HIV组和AIDS组（P〈0.05）。结论综合分析T淋巴细胞不同亚群的改变,能反映HIV感染者和AIDS患者的免疫受损情况和疾病的严重程度。

Changes and Clinical Significance of T-lymphocyte Immunophenotype in HIV-infected People and AIDS Patients

Objective To investigate the T- lymphocyte immune alterations and its clinical significance in HIV- infected persons and AIDS patients in Hengyang. Metheds Peripheral blood samples were collected from 59 HIV - infected persons, 50 AIDS patients, and 31 healthy persons. Flow cytometry was used to detect the counts of CD4 ^＋ T- lymphocytes and CD8 ^＋ T- lymphocytes. Results The T4 cell count was 673 ± 362 cells/ul in control group, which was significantly higher than that in HIV- infected person group （337 ± 278 cells/ul, P〈0.01）, and that in AIDS patient group （129 ± 124 cells/ul, P 〈0.01）. The T8 cell count was 478± 243 cells/ul in control group, which was significantly lower than that in HIV- infected person group （940 ± 844 cells/ul, P 〈 0.05）. T4/T8 ratio （TH/S） was 1.49 ± 0.90 in control group, which was significantly higher than that in HIV-infected person group （0.39± 0.38, P〈0.05） and that in AIDS patient group （0.18 ± 0.17, P〈 0.05）. Conclusions Synthetical analysis of the alterations of different T cell subsets reflects the immune deficiency and severity of the disease.