超声检查测量心踝指数新方法

目的 评估超声方法 测量心踝指数(CAVI)的准确性和可重复性,以及它与振荡法CAVI之间的相互关系,分析CAVI与颈动脉弹性指标的关系.方法 选取进行年度体检者96人(男性64人),年龄22～62岁,平均年龄(41.2±8.9)岁,使用M型及多普勒法分别测量主动脉-踝动脉的脉搏波传导速度(caPWV),经公式计算可分别得出M型心踝指数(CAVIm)和多普勒法心踝指数(CAVId).使用全自动动脉硬化检测设备测量CAVI.在96人中随机抽取20人进行重复性测量:观察者间重复性:每个对象由2名观察者(观察者1和观察者2)以随机顺序进行CAVIm和CAVId测量,两侧测量之间至少相隔5 min.观察者内可重复性:每个对象由观察者1进行2次测量,2次测量之间相隔I d.结果 M型和多普勒法测得的CAVIm和CAVId与振荡法测得的CAVI有良好的相关性(r1=0.925,r2=0.738,P<0.001).观察者内和观察者间CAVIm和CAVId的可重复性Pearson相关显著,单变量分析结果 表明,CAVI、CAVIm和CAVId均和内中膜厚度(IMT)、僵硬度指数(β)显著相关.结论 超声方法 为无创简便地测量CAVI提供了一种新的方法 ,用于评价大动脉弹性功能可重复性好,与振荡法CAVI显著相关.

Evaluation on cardio-ankle vascular index derived from ultrasound

Objective The cardio-ankle vascular index (CAVI) could be obtained by measuring pulse wave velocity (PWV) and blood pressure (BP). This method is associated with various technical drawbacks. We evaluated the accuracy and usefulness of CAVI measured by ultrasound via detecting the aortic and ankle flow directly by ultrasonic probe. Methods CAVI was determined in 96 subjects 64 male, mean age (41.2±8. 9) years] who took part in the annual check up program in our department by means of the professional equipment ( BP-203RPE Ⅱ , VP-1000, Japan, CAVIp), the M-mode (CAVIm) and color Doppler flow imaging (CAVId). Measurement reproducibility on was obtained by repeat the measurements in 20 subjects choose randomly from the 96 subjects. Carotid ultrasound (CU) was performed to obtain intima- media thickness (IMT) and β index in all subjects. Results CAVI obtained by various methods were similar and comparable ( CAVIm 7.74±1. 62, CAVId 7. 77±1.59, CAVIp 8. 74±1.57, all P 0. 05). Inter-group and inter-observer variance was negligible ( r1 = 0. 98, r2 = 0. 97). There were also significant correlations between CAVIm and IMT, CAVIm and β (r1 =0. 824, r2 =0. 812, all P <0. 01 ), and between CAVId and IMT, CAVId and β (r1 =0.815, r2 =0.813, all P<0.01). Conclusions CAVI could be correctly measured by ultrasound technique.