| 早期急性肾损伤标志物肾损伤分子1研究进展 |
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| 引用本文： | 李引,杜晓刚. 早期急性肾损伤标志物肾损伤分子1研究进展[J]. 中国医药导报, 2014, 0(35): 166-168 |
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| 作者姓名： | 李引 杜晓刚 |
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| 作者单位： | 重庆医科大学附属第一医院肾内科,重庆400016 |
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| 摘 要： | 肾损伤分子1（Kim-1）是一种I型跨膜糖蛋白，在正常肾脏中不能检测出，但在肾脏缺血或者毒性损伤后在近端小管细胞的细胞膜顶端表达增强，能够促进损伤的上皮细胞修复。目前越来越多的研究表明Kim-1可能是代表急性肾损伤早期、无创的近端小管生物标志物。
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| 关 键 词： | 急性肾损伤 肾损伤分子1 生物学标志 |
Recent advances of early biomarker kidney injury molecule 1 for diagnosis of acute kidney injury |
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| LI Yin,DU Xiaogang. Recent advances of early biomarker kidney injury molecule 1 for diagnosis of acute kidney injury[J]. China Medical Herald, 2014, 0(35): 166-168 |
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| Authors: | LI Yin DU Xiaogang |
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| Affiliation: | (Department of Nephrology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China) |
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| Abstract: | Kidney injury molecule 1 （Kim-1） is a type Ⅰ transmembrane glycoprotein, which is absent in normal condition but elevated in the proximal tubule apical membrane cells after renal ischemia or toxic injury. Kim-1 is capable of facilitating repair of injured epithelia. Recently, more and more studies show that Kim-1 may represent an early, noninvasive biomarker for proximal tubular acute kidney injury. |
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| Keywords: | Acute kidney injury Kidney injury molecule-l Biomarker |
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