| 上皮-间质转化在眼科的研究进展 |
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| 引用本文： | Liu T,Dong XG. 上皮-间质转化在眼科的研究进展[J]. 中华眼科杂志, 2008, 44(3): 285-288 |
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| 作者姓名： | Liu T Dong XG |
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| 作者单位： | 山东省眼科研究所山东省眼科学重点实验室-省部共建国家重点实验室培育基地,266071 |
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| 基金项目： | 国家自然科学基金,山东省自主创新重大科技专项计划项目,山东省自然科学基金 |
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| 摘 要： | 上皮-间质转化(EMT)是胚胎发育、肿瘤转移和组织修复过程中起关键作用的细胞转型机制.EMT主要表现为上皮细胞的极性、细胞间连接消失,上皮细胞表达间质成分并具有迁移的表型.在眼科疾病中,角膜细胞再生、纤维化以及创伤愈合过程存在EMT机制.EMT也是晶状体外伤、晶状体前囊混浊、后发性白内障以及增殖性玻璃体视网膜病变等疾病的重要发病机制,本文综述眼科领域中EMT机制的研究进展.(中华眼科杂志,2008,44:285-288)
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| 关 键 词： | 上皮细胞 间质干细胞 细胞系,转化 细胞运动 |
The progress of epithelial-mesenchymal transition in ophthalmology |
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| Liu Ting,Dong Xiao-Guang. The progress of epithelial-mesenchymal transition in ophthalmology[J]. Chinese Journal of Ophthalmology, 2008, 44(3): 285-288 |
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| Authors: | Liu Ting Dong Xiao-Guang |
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| Affiliation: | State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Qingdao 266071,China. |
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| Abstract: | Epithelial-mesenchymal transition (EMT), a mechanism of cell transdifferentiation, plays a key role in embryonic development, tumor metastasis and tissue reparative process. The main manifestations of EMT are disappearance of epithelium polarity, lose of cell-cell junction, increased expression of mesenchymal phenotype and activated migratory ability of epithelium. EMT existed in the cornea epithelium regeneration, fibrosis, and wound healing. EMT also participates in the pathological development of lens trauma, cataract and proliferative vitreous retinopathy. This article outlined the recent progress of EMT in ophthalmology. |
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| Keywords: | Epithelial-cells Mesenchymal stem cells Cell line,transformed Cell movement |
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