巨细胞病毒感染的致病机制初探

目的 探讨人巨细胞(HCMV)的致病机制。方法 应用酶联免疫吸附试验(ELISA)对36例早孕人工流产妇女进行了HCMV抗体IgG、IgM的检测，对抗体阳性者的绒毛及蜕膜进行了HCMV的PCR检测，对DNA阳性者进行了绒毛蜕膜的病理切片分析。结果 HCMV免疫抗体阳性的31例患者仅有10例DNA阳性者绒毛蜕膜均发生了明显的病理变化，绒毛细胞滋养层增生过长，蜕膜变性坏死，伴淋巴细胞浸润。结论 绒毛蜕膜的病理改变可能参与了HCMV的致病机制。

Preliminary studies on pathogenic factors of human cytomegalovirus infection

Objective To investigate the pathogenic factors of human cytomegalovirs ( HCMV) infections. Methods Totally 36 serum samples were obtained from early pregnant woman and examined with ELISA for anti-HCMV antibody IgG and IgM. After artificial abortion, chorionic villus and decidua were also examined with polymerase chain reaction (PCR) for HCMV-DNA.When the results of PCR were positive, pathological changes of these chorionic villus and decidua were analyzed. Results The results showed that only 10 samples were PCR positive while IgG and/or IgM antibody to HCMV was positve. After infection with HCMV, different changes occurred in chorionic villus and decidua: trophoblastic cells placental villus were hyperplasic and decidua cells degenerated and necrotized followed by lymphocytes infiltration. Conclusion These pathological changes may be one of pathogenic factors of HCMV.