多囊卵巢综合征患者促甲状腺激素浓度与血脂关系的研究 |
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引用本文: | 殷冬梅,;阮祥燕,;卢永军,;武红琴,;田玄玄,;Diethelm Wallwiener,;Alfred O.Mueck. 多囊卵巢综合征患者促甲状腺激素浓度与血脂关系的研究[J]. 首都医科大学学报, 2014, 0(4): 424-427 |
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作者姓名: | 殷冬梅, 阮祥燕, 卢永军, 武红琴, 田玄玄, Diethelm Wallwiener, Alfred O.Mueck |
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作者单位: | [1]首都医科大学附属北京妇产医院内分泌科,北京100026; [2]德国图宾根大学妇产医院内分泌与绝经中心,德国图宾根D-72076 |
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基金项目: | 国家外专局引智项目(GDJ20141100017);北京市卫生系统高层次卫生技术人才培养计划项目(2009-3-52);首都医科大学附属北京妇产医院、北京妇幼保健院学科带头人项目(2013-1) |
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摘 要: | 目的研究不同浓度血清促甲状腺激素(thyroid-stimulating hormone,TSH)的多囊卵巢综合征(polycystic ovary syndrome,PCOS)患者临床特征及内分泌代谢指标之间的差异。方法选择110例多囊卵巢综合征患者,测量身高、体质量、腰围、臀围;应用化学发光法分析测定血清TSH、总胆固醇(total cholesterol,TC)、低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)、高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)、三酰甘油(triglycerides,TG)、空腹血糖(fasting blood glucose,FBG)、空腹胰岛素(fasting serum insulin,INS)、卵泡刺激素(follicle stimulating hormone,FSH)、黄体生成素(luteinizing hormone,LH)、睾酮(testosterone,T)、催乳素(prolactin,PRL)、雌二醇(estrogen,E2);计算体质量指数(body mass index,BMI)、腰臀比(waist hip ratio,WHR)、黄体生成素与卵泡刺激素的比值(LH-to-FSH ratio,LH/FSH);采用稳态模型评估的胰岛素抵抗指数(homeostasis model assessment insulin resistance,HOMA-IR),按血清TSH浓度将其分为2组:A组71例,TSH0.05)。结论 TSH与脂代谢指标有相关性,TSH≥2.5 mIu/L的PCOS患者,脂代谢发生了显著的变化。
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关 键 词: | 多囊卵巢综合征 促甲状腺激素 脂代谢 |
Association between thyroid-stimulating hormone and serum lipid in patients with polycystic ovary syndrome |
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Affiliation: | Yin Dongmei, Ruan Xiangyan, Lu Yongjun, Wu Hongqin, Tian Xuanxuan, Diethelm Wallwiener, Alfred O. Mueck ( 1. Department of Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China ; 2. Department of Endocrinology, University Women's Hospital of Tubingen, Tubingen D-72076, Germany) |
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Abstract: | Objective To investigate the differences in clinical features , endocrine metabolic parameters of polycystic ovary syndrome patients with different levels of serum thyroid-stimulating hormone .Methods One hundred and ten PCOS patients were enrolled . Height , weight , waist circumference , hip circumferences were measured . Chemiluminescence was applied for measuring thyroid-stimulating hormone(TSH), total cholesterol(TC), low density lipoprotein(LDL), high density lipoprotein(HDL), triglyceride(TG), fasting blood-glucose(FBG), fasting insulin(INS), follicle-stimulating hormone(FSH), luteinizing hormone(LH), testosterone(T), prolactin(PRL) and estradiol(E2);Body mass index(BMI), waist-to-hip circumference ratio(WHR), LH-to-FSH ratio(LH/FSH) were calculated;The insulin resistance index evaluated by steady-state model ( HOMA-IR);all patients were divided into two groups according to serum thyroid-stimulating hormone:group A had 71 cases with TSH〈2.5 mIu/L, as group B of 39 cases with TSH≥2.5 mIu/L; all the hormone parameters mentioned above were compared between group A and B , and the correlation with TSH .Results The WHR and LDL in group B(TSH≥2.5 mIu/L) is significantly higher than that of the patients in group A (TSH〈2.5 mIu/L).The increase of TSH concentration positively correlates to an increase of WHR , TC, LDL-C and PRL.No significant differences are shown in other clinical and metabolic indicators.Conclusion There was a significant correlation between TSH and lipid metabolic parameters .Women with polycystic ovary syndrome and with thyroid-stimulating hormone≥2.5 mIu/L had significantly endocrine and metabolic changes . |
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Keywords: | polycystic ovary syndrome thyroid-stimulating hormone lipid metabolism |
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