液基细胞学技术与传统细胞学涂片检测宫颈鳞状细胞病变差异评价

目的比较液基细胞学技术与传统细胞学涂片在宫颈鳞状细胞病变检测中的差异。方法 2008年1月—2012年1月采用液基细胞学技术及传统细胞学涂片对1 880名妇女进行筛查,并对筛查阳性病例以阴道镜检查及病理活检结果为金标准作为阳性对照,评估液基细胞学技术对宫颈不同病变的诊断价值。结果液基细胞学筛查出非典型鳞状细胞(atypical squamous cells of undeter mined significance,ASCUS)及以上病例282例,阳性检出率为15.0%;传统细胞学涂片筛查出巴氏ⅡB级及以上病例84例,阳性检出率为4.5%。液基细胞学阳性检出率明显高于传统细胞学涂片,二者比较差异有统计学意义(P0.05)。以阴道镜及病理组织学检查结果为金标准,液基细胞学筛查符合率为73.40%,传统细胞学涂片筛查符合率为53.57%,二者比较差异有统计学意义(P0.05)。结论液基细胞学技术筛查宫颈鳞状细胞病变明显优于传统细胞学涂片。

Comparison of liquid-based cytology and conventional cytology smears in detecting cervical squamous cell lesions

Objective To compare the value of liquid-based cytology and conventional cytology smears in the detection of cervical squamous cell lesions.Methods From January 2008 to January 2012,1 880 women were detected by cervical liquid-based cytology and conventional cytology smear screening.With the gold standard of colposcopic and biopsy findings,positive cases were selected as the controls.The results were statistically analyzed to assess the diagnostic value of liquid-based cytology for cervical lesions.Results 282 cases who had received liquid-based cytologic detection were found to have ASCUS and above lesions,the positive detection rate of was 15.0%;and 84 cases,pap Ⅱ B level and above lesions,4.5%.The positive detection rate by liquid-based cytology was significantly higher than that of conventional cytology smears,with statistically significant difference(P<0.05).With the gold standard of colposcopic and histopathological findings,the coincidence rate of cervical liquid-based cytology screening and conventional cytology smear screening was 73.4% and 53.6% respectively,and the difference was statistically significant(P<0.05).Conclusion Liquid-based cytology screening for cervical squamous cell lesions is significantly better than conventional cytology smears.