| 流动剪切力作用下原代大鼠成骨样细胞PGE2的表达 |
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| 引用本文： | 乔鞠,陈伟辉,李声伟,罗颂椒,田卫东,张敏,李强.流动剪切力作用下原代大鼠成骨样细胞PGE2的表达[J].华西口腔医学杂志,2001,19(2):86-88. |
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| 作者姓名： | 乔鞠 陈伟辉 李声伟 罗颂椒 田卫东 张敏 李强 |
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| 作者单位： | 四川大学华西口腔医学院, |
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| 基金项目： | 本课题为国家自然科学基金资助项目(编号
39600167) |
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| 摘 要： | 目的探讨流动剪切力调节成骨细胞增殖和分化的信号转导过程中PGE
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| 关 键 词： | 流动剪切力 成骨样细胞 PGE2 信号转导 大鼠 细胞增殖 |
| 修稿时间： | 2000年8月21日 |
Effects of Fluid Shear Stress on PGE2 Synthesis of Primary Osteoblast-like Cells in Rats |
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| Qiao Ju.Effects of Fluid Shear Stress on PGE2 Synthesis of Primary Osteoblast-like Cells in Rats[J].West China Journal of Stomatology,2001,19(2):86-88. |
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| Authors: | Qiao Ju |
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| Institution: | College of Stomatology, West China University of Medical Sciences. |
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| Abstract: | OBJECTIVE: The purpose of this study is to study the function of PGE2 during the signal transduction in which fluid shear stress regulates the proliferation and differentiation of osteoblast-like cells. METHODS: The isolated rat primary osteoblast-like cells were exposed to fluid shear stress 0.12 mN/cm2 for 5, 10, 15, 30, 60 and 120 minutes respectively in a flow chamber. The release of PGE2 was examined. RESULTS: After exposure to fluid shear stress, the PGE2 synthesis of rat primary osteoblast-like cells increased significantly (P < 0.01) when compared with the control. After 10 minutes, the release of PGE2 began to increase significantly (P < 0.01) and the effect was maximal after 60 minutes (P < 0.01). CONCLUSION: PGE2 pathway may be one of the signal-transduction pathways which can transduce the fluid shear stress into osteoblast-like cells and then stimulate the bone remodeling. |
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| Keywords: | PGE2 |
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