A multigene RT-PCR assay used to predict recurrence in early breast cancer: two presentations with contradictory results |
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Authors: | Willem E Fiets Johan WR Nortier |
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Institution: | (1) Department of Medical Oncology, Leiden University Medical Center, The Netherlands |
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Abstract: | During the 2003 San Antonio Breast Cancer Symposium two studies were presented that were designed to validate a recurrence score, derived from a 21-gene RT-PCR assay, in patients with axillary node-negative breast cancer. This recurrence score was highly predictive for the risk of recurrence in 668 patients treated in a large multicenter trial with adjuvant tamoxifen. However, no prognostic value was found in a small group of patients who were retrospectively selected in a single institution and who did not receive any adjuvant systemic therapy. Further validation is needed to establish the prognostic and predictive role of this assay in clinical management. |
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Keywords: | breast cancer predictive marker prognostic marker RNA |
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