乳腺前体T淋巴母细胞淋巴瘤一例并文献复习

目的 提高对乳腺前体T淋巴母细胞淋巴瘤(preT-LBL)的认识.方法 报道乳腺淋巴瘤1例,并复习有关乳腺非霍奇金淋巴瘤及表现为乳腺肿块的pre T-LBL的文献.结果 确诊乳腺pre T-LBL 1例,患者表现高白细胞、乳腺多个肿块伴多发浅表淋巴结肿大,经积极支持治疗同时予Hyper-CVAD方案化疗1个疗程,获得完全缓解(CR),原方案巩固3个疗程,无病生存期达5个月.结论 乳腺淋巴瘤是较少见的恶性肿瘤.pre T-LBL是一种高度侵袭性疾病,预后不良.选择多种药物的联合化疗,可以延长生存期,提高疗效.

Precursor T-lymphoblastic lymphoma of the breast: one case report and reviews of literature

Objective To improve the recognition of precursor T- lymphoblastic lymphoma (T-LBL)of the breast. Methods One case of breast T- LBL was reported, the development of breast non-Hodgkin lymphoma and T-LBL presenting as breast masses was reviewed. Results One case of breast T-LBL was diagnosed, the patient with a high leukocyte count, breast mass and peripheral lymph nodes was treated with Hyper-CVAD regimen after active therapy and achieved complete remission (CR). Followed by maintenance therapy with Hyper-CVAD regimen for three times, disease free survival had been obtained five month.Conclusion Lymphoma of the brest is a rare malignancy. T-LBL is a highly aggressive disease with adverse prognosis, it is very uncommon for presenting as lymphoma of breast. Initiation of intensive muhiagent chemotherapy can improve the free survival and the prognosis.