| 脑缺血后脑细胞线粒体LPO、SOD的变化 |
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| 引用本文： | 卞留贯,张天赐,赵卫国.脑缺血后脑细胞线粒体LPO、SOD的变化[J].中国神经精神疾病杂志,1994(1). |
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| 作者姓名： | 卞留贯 张天赐 赵卫国 |
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| 作者单位： | 上海第二医科大学附属瑞金医院神经外科 200025
(卞留贯，张天赐)，上海第二医科大学附属瑞金医院神经外科 200025(赵卫国) |
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| 基金项目： | 上海市科委“脑缺血”课题基金资助 |
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| 摘 要： | 我们利用兔MCAO模型,分别测定脑缺血后4h(I_4)、24h(I_(24))脑组织的H_2o、Na~ 、Ca~(2 )、LPO,SOD以及线粒体的LPO,SOD,经与对照组(包括假手术和正常对照)对比,结果发现脑缺血后脑组织H_2o、Na~ 、C_a~(2 )LPO及线粒体LPO均明显增加,而SOD活性变化则相反地降低。结果提示脑缺血后脑细胞线粒体的LPO含量增加,而SOD活性则下降,说明脑缺血后线粒体产生的自由基参与了脑缺血脑损伤机制。
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| 关 键 词： | 脑缺血 线粒体 MCAO LPO SOD |
Changes of mitochondrial LPO,SOD after cerebral ischemia. |
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| Bian Liuguan,et al..Changes of mitochondrial LPO,SOD after cerebral ischemia.[J].Chinese Journal of Nervous and Mental Diseases,1994(1). |
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| Authors: | Bian Liuguan |
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| Affiliation: | Bian Liuguan,et al.
Department of Neurosurgery,Ruijin Hospital?SSAtU. Shanghai. 200025 |
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| Abstract: | Using the model of rabbit middle cerebral artery occlusion (MCAo), we measured the contents of LPO, the activity of SOD of brain tissure and mitochondrion in ischemic groups (14. 4h after cerebral ischemia, I24 24h after cerebral ischemia). The contens of H2o, Na , Ca2 were also determined. We found that the contents of brain tissue' s H2o, Na4 , Ca2 , LPO and mitochondrial LPO were significantly increased compared to control, however, the activity of SOD of brain tissue and mitochon- drial changed opposite, significantly decreased. These results suggested that the oxygen free radicals produced by mitochondrion were increased after cerebral ischemia, which resulted in the deterious mitochondrion structure and function and the damage of cells. |
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| Keywords: | Cerebral ischemia Mitochondrion MCAo LPO SOD |
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