青光眼滤过术中γ-干扰素抗增殖作用的临床观察

目的 研究γ-干扰素在青光眼滤过术中的抗增殖作用。方法 采用随机对照的临床研究方法,64例80眼施行统一标准小梁切除术的晚期原发性青光眼分为用药组及对照组各40眼,均为初次手术。于术后当时、术后第3、7、14天结膜下注射γ-干扰素500×10~3IU,对照组未用药物。进行滤 过泡、滤过功能及眼压观察。随访12～24个月 结果 手术成功率:用药组92.2％,对照组80％;功能性滤过泡数:用药组35/60,对照组25/60。非功能性滤过泡:用药组6眼,对照组14眼。治疗组未见明显全身及局部副作用。结论 γ-干扰素可以改善滤过功能,降低眼压,提高手术成功率且无毒副作用,是安全有效的抗增殖药物,临床上可推广使用。

Clinical observation of the antiproliferative effects of γ-interferon on glaucoma filtering operation

Objective To study the antiproliferative effects of y-interferon on glaucoma filtering surgery. Methods In a randomized control clinical study,64 patients (80 eyes)with late stage of primary open-angle glaucoma underwend trabeculectomy with and without y-interferon,each group consisting of 40 eyes. All eyes received the surgery the first time, y-interferon (500 X 10' 1U) was subconjunctivally injected at the filling bleb during the operation, on the 3rd, 7th, 14th day after operation. In the control group, drug was not used, then filtering bleb, filtering function and IOP were observed. The follow-up period was 12 ~ 24 months. Results The cumulative success probability rate in y-interferon group was 92. 2% , and that in control group was 80% . The number of eyes with functional fitering blebs was 35/ 60,and without drug was 25/60. There were no significant side-effect in y-interferon group. Conclusion The result show that y- interferon can reduce the scar, improve filtering function, stabilize IOP and have no toxic reaction. It is a safe and effective antiproliferative agent for the use in glaucoma filtering surgery, and can be tried clinically.