| 神经生长因子及其受体与神经系统肿瘤的关系 |
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| 引用本文： | 杨勇.神经生长因子及其受体与神经系统肿瘤的关系[J].国际肿瘤学杂志,2008,35(10):735-738. |
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| 作者姓名： | 杨勇 |
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| 作者单位： | 江苏大学附属人民医院神经外科江苏大学临床医学院,镇江,212002 |
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| 基金项目： | 国家自然科学基金，江苏省镇江市社会发展基金 |
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| 摘 要： | 研究表明神经生长因子(NGF)及其高亲和力受体酪氨酸激酶受体(TrkA)在神经系统肿瘤中表达发生改变,并且NGF及TrkA的高表达预示着神经母细胞瘤(NB)和髓母细胞瘤(MB)的良好预后,而在胶质瘤,NGF及TrkA的高表达和核转位与肿瘤的恶性程度密切相关.研究NGF及TrkA在神经系统肿瘤中的表达及亚细胞定位将为肿瘤的诊疗开辟新途径.
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| 关 键 词： | 神经生长因子 受体 神经生长因子 肿瘤 神经上皮 |
Nerve growth factor and its receptors in tumors of nervous system |
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| YANG Yong.Nerve growth factor and its receptors in tumors of nervous system[J].Journal of International Oncology,2008,35(10):735-738. |
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| Authors: | YANG Yong |
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| Abstract: | Nerve growth factor (NGF) and its high affinity receptor tyrosine kinase (TrkA)are indis-pensable for the development of nervous system. Latest researches reveal that over-expression of NGF and TrkA is related to better outcome in neuroblastoma and medulloblastoma. While in glioma, the over-expression and nuclear translocation of NGF and TrkA are indicators of malignant degree. Study of the expression and sub-cel-lular cocalization of NGF and TrkA can provide new way for the diagnosis and therapy of nervous system tumors. |
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| Keywords: | Nerve growth factor Receptors nerve growth factor Neoplasms neuroepithelial |
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