重症H1N1流感病毒感染小儿器官功能评估

目的研究重症H1N1流感病毒感染小儿器官系统功能衰竭情况。方法 PCR检测H1N1流感病毒RNA阳性重症患者32例,按小儿多器官功能衰竭诊断标准对各器官系统进行评估。结果 (1)重症H1N1流感病毒感染小儿呼吸系统与中枢神经系统功能衰竭发生机率最高,分别为46.88%与12.5%;(2)其他器官系统功能衰竭未见单独出现,多与呼吸与神经系统异常伴发;(3)急性坏死性脑病是重症H1N1流感病毒感染小儿死亡的重要原因。结论重症H1N1流感病毒感染小儿呼吸系统与神经系统功能衰竭发生机率高,值得临床医生注意。

Evaluation of the organ function in children with severe human swine influenza A (H1N1) infection

Objective To study organ function of children with severe human swine influenza A (H1N1) infection. Methods Thirty-two children with severe H1N1 influenza infection was confirmed polymerase-chain reaction (PCR) and the function of the organs was assessed according to the criteria of organ and system dysfunction in children. Results The incidence of organ dysfunction were highest in the respiratory system and central nervous system (46.88% and 12.5%, respectively); Dysfunction in other organs was accompanied by abnormality of respiratory system and central nervous system; Acute necrotizing encephalopathy was the major cause of death in children with severe H1N1 influenza infection. Conclusion Respiratory system and central nervous system in children with severe H1N1 influenza infection are susceptible to injury, which should be paid attention to by clinical physicians.