生长激素激发试验在矮小症诊治中的临床价值

目的评价生长激素(Growth hormone,GH)激发试验对儿童GH缺乏症诊断的临床价值。方法对2008年8月至2010年9月年间收住院的26例矮小患儿应用精氨酸与可乐定两种药物做生长激素激发试验,GH测定采用放射免疫法,记录结果并分析。结果药物激发后GH峰值在30min和90min出现最多,GH完全缺乏者4例,占15.38%;部分缺乏者4例,占15.38%;完全不缺乏者18例,占69.23%。结论矮小患儿有部分是GH完全缺乏或部分缺乏所致。精氨酸与可乐定联合激发试验可作为临床诊断GH缺乏症的确认方法之一。

linical value of the growth hormone stimulation test in the diagnosis and treatment of short stature

Objective To evaluate the value of the growth hormone (GH) stimulation test in the diagnosis of GH deficiency.Methods Twenty-six hospitalized children with short stature from August 2008 to September 2010 were tested with combined arginine and clonidien stimulation.GH was measured by radioimmunoassay.The test results were recorded and analyzed.Results GH was stimulated to the maximum 30 minutes and 90 minutes after the tests.Four children showed complete GH deficiency,accounting for 15.38%.Another four children showed partial GH deficiency,accounting for 15.38%.The rest 18 children did not lack GH at all,accounting for 69.23%.Conclusion For some children,short stature is caused by GH deficiency or partial GH deficiency.Argine and clonidine stimulation test can be used as a confirmation for GH deficiency.