Relationship of platelet MAO activity to characteristics of major depressive illness |
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| Authors: | A Georgotas R E McCue E Friedman W E Hapworth O M Kim T B Cooper I Chang P E Stokes |
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| Institution: | 1. Anastasios Georgotas, M.D., is Professor of Psychiatry and Director, Depression Studies Program, New York University School of Medicine. Robert E. McCue, M.D., is Clinical Instructor of Psychiatry, New York University School of Medicine. Eitan Friedman, Ph.D., is Associate Professor of Psychiatry and Pharmacology, New York University School of Medicine. William E. Hapworth, M.D., and O. Mary Kim, M.D., are Postdoctoral Fellows, New York University School of Medicine, USA;2. Thomas B. Cooper, M.A., is Associate Professor of Clinical Psychopharmacology in Psychiatry, College of Physicians and Surgeons, Columbia University, and Chief, Analytical Psychopharmacology Laboratory, Nathan Kline Institute and New York State Psychiatric Institute, USA;3. Irene Chang, B.A., is Senior Project Assistant, Depression Studies Program, New York University Medical Center, USA;4. Peter E. Stokes, M.D., is Professor of Psychiatry, Associate Professor of Medicine (Endocrinology), and Chief, Division of Psychobiology, Payne Whitney Clinic, Cornell University School of Medicine, USA |
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| Abstract: | Sixty-seven patients (greater than or equal to 55 years of age) with major depressive disorder had pretreatment assays of platelet monoamine oxidase (MAO) activity. As in previous studies, women had higher MAO activity than men, and MAO activity was positively correlated with age. Patients with melancholia (DSM-III) had significantly higher MAO activity than those without melancholia. This finding may reflect the higher MAO activity associated with the symptoms of anhedonia and mood autonomy. Anxiety also was correlated with higher MAO activity, as was a positive family history of depression. In addition, postdexamethasone cortisol levels were correlated with platelet MAO activity. |
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