皮肤恶性淋巴瘤和淋巴样细胞浸润的增殖细胞核抗原的表达

PC10免疫染色检测24例皮肤恶性淋巴瘤(CML)和8例良性皮肤淋巴样细胞浸润(CLI)患者回顾性皮肤活检标本的石蜡包埋组织。统计学上,皮肤真性组织细胞性淋巴瘤(CGHL)、皮肤生发中心细胞性淋巴瘤(CGCCL)、非蕈样肉芽肿(MF)和Sezary综合征(SS)之皮肤外周T细胞淋巴瘤(CPTL)和MF的PC10指数与CLI比较,其差异有显着性意义。PC10指数与PC10密度的平方根之间有线性关系,两者与CML的严重性似呈平行关系。PC10免疫染色阳性瘤细胞或淋巴细胞的核容积也有助于鉴别CML与CLI.

Expression or proliferating Cell Nuclear Antigen In Cutaneous Malignant Lymphomas and Lymphoid Infiltrates

Paraffin - embedded tissue of skin biopsy specimens taken retrospectively from 24 patients with cutaneous malignant lymphomas(CML) and 8 patients with cutaneous benign lymphoid infiltrates (CLI) and other dermatoses were estimated with PC10 immunostaining. Our results show a statistical significant difference between PC10 indices for cutaneous genuine histiocytic lymphoma(CGHL), cutaneous germinal center cell-derived lymphomas(CGCCL), cutaneous peripheral T-cell lymphomas(CPTL) other than mycosis fungoides(MF) and Sezary's syndrome (SS),and MF when compared with those for CLI. There is a linear relationship between PC10 index and square root of PC10 density, both of which seem to have a parallel relationship to the seventy of malignancy in CML. The nuclear volume of the positive tumor cell or lymphocyte with PC10 immunostaining may be also useful in differentiating CML from CLI.