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Effects of ergothioneine on diabetic embryopathy in pregnant rats |
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| Authors: | M. V. Guijarro A. Indart O. I. Aruoma M. Viana B. Bonet |
| Affiliation: | a Facultad de Ciencias Experimentales y Técnicas, Universidad de San Pablo CEU, PO Box 67, 28660 Boadilla del Monte, Madrid, Spain b Department of Neuroinflammation, Division of Neuroscience and Psychological Medicine, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Charing Cross Hospital Campus, Fulham Palace Road, London W6 8RF, UK c Area de Pediatría y Neonatología, Fundación Hospital de Alcorcón, C/ Budapest S/N, Alcorcón, 28922, Madrid, Spain |
| Abstract: | The natural antioxidant ergothioneine (2-mercaptohistidine trimethylbetaine) is a fungal metabolite and found in most plant and animal tissues. The effect of ergothioneine on diabetic embryopathy in rats was assessed. Supplementation of diabetic pregnant rats with -ergothioneine (1.147 mg/kg body weight) daily for the first 11.5 days of pregnancy reduced the rate of embryo malformations, to values similar to the non-diabetic animals. The ergothioneine had no effect on the plasma glucose levels, both in diabetic and control animals. We conclude that the inhibition of the glucose-mediated free radical dependent embryo malformation by ergothioneine is an important antioxidant prophylactic mechanism, which when combined with vitamin E could benefit the management of diabetic embryopathy. |
| Keywords: | Ergothioneine Diabetic pregnancy Embryo malformations Antioxidants Neural tube defects Diabetic pregnancy |
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