氯沙坦对充血性心力衰竭远期预后的影响

目的观察血管紧张素Ⅱ受体阻滞剂(ARB)治疗充血性心力衰竭(CHF)的远期预后.方法选择CHF患者64例,随机分为对照组(28例)和观察组(36例).对照组采用综合疗法.观察组在上述基础上加用氯沙坦(50～100mg/d).在治疗前和观察期满3年时,分别进行超声心动图检测左室射血分数(LVEF)、每搏输出量(SV)、心脏指数(CI).结果3年间,对照组和观察组因心力衰竭加重再住院率分别为75.0%和25.0%(P＜0.05),病死率分别为32.5%和8.3%(P＜0.05);与治疗前相比,观察组心功能(NYHA)分级,LVEF、SV、CI均显著改善(P＜0.01),而对照组无明显改善.结论氯沙坦可显著改善CHF患者的远期预后.

THE EFFECT OF LOSARTAN ON PROGNOSIS OF PATIENTS WITH CONGESTIVE HEART FAILURE

Objective To investigate the long - term effect of Losartan on the patients with congestive heart failure (CHF). Methods 64 CHF patients were divided into the treatment group (36 cases)and the control (28 cases) randomly. The general therapy was given to the control. Besides general therapy, Losartar (50 mg-100mg/d) was added to the treatment group. LVEF,SV,CI were measured by heart Doppler ultrasound before and end of 3-year treament. Results The rehospitalization rate was 75. 0% in the control and 25. 0% in the treatment group (P<0. 05). The mortality rate was 32.1 % in the control and 8.3% in treatment group. LVEF, SV, CI improved significantly in treatment group (P < 0.01), but did not Change significantly in the control. Conclusion The long - term prognosis could be improved by Losartan in CHF patients.