贻贝多糖对老龄SD大鼠抗衰老作用

目的:研究贻贝多糖对老龄大鼠抗衰老的生物效应。方法:建立24个月龄SD大鼠自然衰老模型,分为老年正常对照组、贻贝粉组(1 g/kg)、贻贝多糖低剂量组(200 mg/kg)、贻贝多糖高剂量组(400 mg/kg),3个月龄大鼠5只为青年对照组,灌胃给药(1次/d);观察大鼠心脏、肝脏、肾、脾的脏器指数,对其心脏、肝脏进行切片观察病理学变化,测定大鼠血清及肝脏中超氧化物歧化酶(SOD)、 谷胱甘肽过氧物酶(GSH-Px)、丙二醛(MDA)水平,测定血清主要生化指标。结果:与老年组相比,贻贝多糖高剂量组的心脏、肝脏病理切片H-E染色观察未见明显衰老性改变,其血清、肝脏中SOD、GSH-Px 水平增高(P<0.01),MDA含量降低(P<0.01)。结论: 贻贝多糖具有抗衰老作用,抗氧化作用可能是其抗衰老作用的机制之一。

Anti-aging activity of Mytilus coruscus polysaccharide in aged SD rats

Objective:To investigate the anti-aging activity of Mytilus coruscus polysaccharide (MP) in aged rats.Methods:We established a 24-month natural aging rat model.Twenty model rats were divided into 4 groups,namely,the aging model group,Mytilus coruscus powder group (MCP 1 g/kg),high dose MP group (MP 400 mg/kg),and low dose MP group (MP 200 mg/kg).Five three-month-old rats served as young control.The Mytilus coruscus power solutions and MP solutions were given intragastrically on a daily basis for 90 days.The organ indices of the heart,liver,kidney,and spleen of rats were observed; the pathology of the hearts and livers was also observed.The levels of superoxidedismutase (SOD),glutatio-neperoxidase (GSH-Px),and malonaldehyde(MDA) in the serum and liver were determined; and the main serum parameters were also determined.Results:Compared with the aging model group,the heart and liver pathology had no obvious aging changes in the high dose MP group.The serum and liver SOD,GSH-Px levels were significantly higher in the high dose MP group than those in the aging model group (P<0.01); the MDA level was significantly lower than those in the aging model group (P<0.01).Conclusion:The Mytilus coruscus polysaccharide possess anti-aging activity,and the anitoxidative effect might be one of the mechanism for the anti-aging effect.