基于QCT数据应用计算机辅助检测系统软件对股骨颈骨密度测量的研究

目的：通过分析基于QCT数据计算机辅助检测系统（CAD）与双能X线吸收仪（DXA）在股骨颈骨密度（BMD）测量上的相关性，探讨基于QCT数据CAD在BMD检测的准确性、有效性。方法：本研究通过中国医科大学盛京医院伦理委员会同意招募50例健康志愿者，平均年龄57岁，男9例，女41例。本研究对象均行Philips Brilliance型64排螺旋CT扫描和Norland XR-36型DXA测量股骨颈BMD，螺旋CT扫描时垫有CT设备通用性体模的双股骨上段。应用OsteoCAD1．1软件分析同侧股骨颈CT数据，测得BMD。应用SPSS 11．0统计、对比OsteoCAD软件分析测量股骨颈BMD和DXA测量股骨颈骨密度的各组数据。结果：①OsteoCAD软件分析测量股骨颈BMD结果：松质骨BMD：均值（216．05±60．80）mg／cm^3；整体骨BMD：均值（344．61±66．93）mg／cm^3；皮质骨BMD：均值（538．54±60．95）mg／cm^3。DXA测量股骨颈BMD结果：均值（0．8029±0．1265）g／cm^2。②SPSS Linear Regression法显示上述两组数据均呈直线相关，相关系数分别为 r松质骨=0．873、r整体骨=0．817、r皮质骨＝0．735，经t检验，相关系数均具有高度的统计学意义（P〈0．001）。结论：OsteoCAD软件能够自动划分并测量皮质骨、小梁骨，和测量股骨颈长度及最小截面积，可以准确、有效地反映骨强度信息。

Research on femoral neck BMD with CAD based on QCT data

Objective： To evaluate the clinical value of computer-aided diagnosis（CAD） based on QCT data in bone density measurement, through analyzing the correlation of trabecular bone mineral density（BMD）, integral BMD, cortical BMD measured by CAD based on QCT data and BMD measured by DXA. Materials and Methods： BMD of femoral neck in 50 patients was measured. Trabecular, integral, cortical BMD were measured by CAD based on QCT data and by DXA. SPSS was used to analyze their relationship. Results： The correlation of trabecular BMD, integral BMD, cortical BMD measured by CAD based on QCT data and BMD measured by DXA were at a high level of significance （P〈0.001）. The correlation of trabecular BMD measured by CAD based on QCT data and BMD measured by DXA was the highest （r=0.873）. Conclusion： CAD based on QCT data could automatically and accurately calculate the femoral neck BMD. It is a useful method to measure BMD.