肝素治疗不稳定心绞痛临床观察

对１８０例不稳定心绞痛随机单盲分为常规治疗（对照组）及常规＋肝素治疗（肝素组）。结果显示，肝素组１周显效率４４．８％，总有效率６７．８％；２周总有效率９３．２％，高于对照组（Ｐ＜０．０５）。２周显效率８７．３％，明显高于对照组（Ｐ＜０，０１）。住院期间心肌梗塞发生率：肝素组３．５％，对照组７．５％（Ｐ＞０．０５）。在院期间病死率：肝素组２．３％，对照组３．２％（Ｐ＞０．０５）。肝素治疗未见明显不良反应。认为肝素与常规药物并用治疗不稳定心绞痛，能迅速控制心绞痛，对降低心肌梗塞发生可能有益。

EFFECT OF HEPARIN ON UNSTABLE ANGINA PECTORIS

One hundred and eighty consecutive cases of unstable angina admitted to our hospital were randomly divided into 2 groups i. e. heparin group (87 cases, 5075 mg heparin sodium salt/12 h i. v. dripor 5000-7000 U heparin calcium salt/12 h subcutaneously plus conventional medicine )and control group ( 93 cases , conventional therapy). The results showed that in the heparin group prominent effect and overall effect were 44. 8% and 67. 8% in the first week , 87. 3% and 93. 2% in the second week , respectively(p<0. 05 and 0. 01 , vs. control). The incidence of acute myocardial infarction during hospitalization was 3. 5% in the heparin group and 7. 5% in the control group(p<0.05) , while the mortality rates were 2.3% and 3.2%, respectively (p> 0. 05). There was no obvious adverse reaction during heparin administration. It was considered that heparin combined with conventional medication could control unstable angina quickly while its effect in reducing the incidence of AMI remained uncertain.