软骨凝集蛋白与C-myc在人非小细胞肺癌中的表达及其意义

目的：探讨软骨凝集蛋白（Chondrolectin, CHODL）与C-myc在人非小细胞肺癌中的表达及其与临床病理特征之间的关系。方法采用免疫组织化学方法检测53例非小细胞肺癌石蜡标本以及43例癌旁对照组织标本，并进行相关分析。结果 CHODL主要分布在胞质与胞膜中，其在癌组织中的阳性表达率为79.25%，明显高于在癌旁组织中的表达（18.60%），C-myc在癌组织中的表达率为60.37%，明显高于其在癌旁组织中过度表达（30.23%），且差异均具有统计学意义；CHODL在癌组织中的表达与淋巴结转移有关，而与年龄、性别、组织分化、TNM分期、肿块大小均无关；C-myc在非小细胞肺癌组织中的表达与淋巴结转移、组织学分化、TNM分期有关（P〈0.05），与年龄、性别、肿块大小无关（P〉0.05），且差异具有统计学意义；CHODL与C-myc在肺癌组织中的表达呈正相关。结论 CHODL在肺癌组织中的作用可能与C-myc呈某种程度的相关性，并与肿瘤淋巴结转移相关，为CHODL在肿瘤转移方面打下基础。

Expression and clinical significance of chondrolectin and C-myc in human non-small cell lung cancer.

Objective To explore the expression and clinical significance of chondrolectin and C-myc in hu-man non-small cell lung cancer and their clinical implication. Methods Immunohistochemical study was carried out to examine the expression of chondrolectin and C-myc and its association with clinicopathologic features in human non-small cell lung cancer. Results The positive rate for chondrolectin and C-myc expression in squamous tissues （79.25%and 60.73%） was significantly higher than those in non-tumor tissues （18.60%and 30.23%）;the positive ex-pression of chondrolectin was not correlated with the patient＆#39;s gender, age and histologic differentiation except that lymph node metastasis, the positive expression of C-myc was correlated with the patient＆#39;s lymph node metastasis, his-tologic differentiation and TNM stage, but without gender, age and size. In non-small cell lung cancer chondrolectin was positively correlated with C-myc. Conclusion Chondrolectin may be an important molecular marker in human non-small cell lung cancer.