血清抵抗素与吸烟者动脉弹性的相关性研究

目的测定吸烟者血清抵抗素水平，并行颈动脉ET技术（血管回声跟踪技术）检测，探讨血清抵抗素水平与动脉弹性的关系。方法选择非吸烟者38例，吸烟者45例，检测血压、身高、体重、体重指数（BMI）、生化指标、血清抵抗素水平，并应用ET技术检测颈动脉压力应变弹性系数（Ep）、僵硬度（β）、顺应性（AC）、增大指数（AI）及脉搏波传导速度（PWVβ）。结果（1）吸烟组Ep、β、AI及PWVβ均高于非吸烟组，差异有统计学意义（P〈0．05）；AC低于非吸烟组，差异有统计学意义（P〈0．05）。（2）血清抵抗素水平与β、P、PWVβ呈正相关关系（r=0．346，P=0．003；r=0．305，P=-0．009）。结论吸烟者血清抵抗素水平与β、PWVβ有相关性，三者均是早期发现动脉弹性病变的敏感指标。

Correlation study of serum resistin and artery elasticity function in smokers.

Objective To study the relationship of the level of serum resistin and artery elasticity function by measuring the level of serum resistin in smokers and detecting E-tracking technique of carotid artery. Methods Forty-five smokers （smokers group） and thirty-eight non-smokers （non-smokers group） were selected. Blood Pressure, height, weight, body mass index （BMI）, biochemical index and level of serum resistin were detected, and pressure-strain elastic modulus （Ep）, stiffness parameters （fl）, arterial compliance （AC）, augment index （AI）, and pulse wave conducting velocity （PWVfl） of Carotid Artery were measured by E-Tracking Technology. Results （1） Ep, fl, AI and PWVfl in smokers group were higher than those in non-smokers group, and there was statistically significant difference （P〈0.05）. AC in smokers group were lower than that in non-smokers group, and there was statistically significant difference （P〈0.05）. （2） The level of serum resistin was positively related with fl and PWVfl （r=0.346, P=0.003; r=0.305, P=0.009）. Conclusion The level of serum resistin has correlation with/3 and PWV/3. Furthermore, serum resistin, 13 and PWVI3 are sensitive indexes of early-detecting artery elasticity lesions.