早期联合低分子肝素钙和阿司匹林治疗急性脑梗死的疗效观察

目的:观察低分子肝素钙、阿司匹林及其早期二者联合应用治疗急性脑梗死的临床疗效。方法:320例急性脑梗死患者随机分为低分子肝素钙组、阿司匹林组、低分子肝素钙和阿司匹林联合治疗组及对照组。对各组分别进行临床疗效等判定。结果:所有治疗组的神经功能恢复明显优于对照组;联合治疗组的神经功能恢复和临床疗效明显优于单独给药组;每组发病后接受治疗时间不同的总有效率有显著性差异(P<0.05);各组出血等不良反应发生率无显著性差异(P>0.05)。结论:急性脑梗死早期联合低分子肝素钙和阿司匹林治疗安全、有效,明显优于单独给药治疗。

Combination of Low Molecule Heparin Calcium with Aspirin for Early Acute Cerebral Infarction

OBJECTIVE ：To evaluate the clinical efficacy of combination of low molecule heparin calcium with Asipilin for early acute cerebral infarction. METHODS： A total of 320 patients with early acute cerebral infarction were randomly assigned to low molecule heparin calcium group, aspirin group, combination treatment group （low molecule heparin calcium group plus aspirin） or control group. The clinical efficacy in 4 groups was evaluated respectively. RESULTS： The nerve function showed a better recovery in all the treatment groups than in control group. As compared with low molecule heparin calcium group or aspirin group, the combination treatment group showed a significantly improved nerve function and higher clinical efficacy. There were significant differences in total effective rate among groups after treatment for different time （P〈0.05） . The incidence of adverse reactions showed no significant difference among groups （P 〉 0.05） . CONCLUSION： The combination of low molecule heparin calcium with Asipilin for early acute cerebral infarction is safe and more effective than low molecule heparin calcium and Asipilin used alone.