| 2-甲酰氨基-噻唑基-4-乙酸的合成 |
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| 引用本文： | 王晖,魏玉斌. 2-甲酰氨基-噻唑基-4-乙酸的合成[J]. 黑龙江医药, 2004, 17(4): 285-286 |
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| 作者姓名： | 王晖 魏玉斌 |
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| 作者单位： | 黑龙江大学化学化工与材料学院,150080;哈尔滨制药总厂 |
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| 摘 要： | 目的：合成头孢替安中间体2-甲酰氨基一噻唑基-4-乙酸；方法：以2-氨基-噻唑基-4-乙酸乙酯为原料，经甲酰化、水解两步反应制备得到。用IR进行结构鉴定；结果：总收率为70％；结论：本方法工艺条件温和，收率高，成本低，适合工业化生产。
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| 关 键 词： | 2-甲酰氨基-噻唑基-4-乙酸 2-氨基-噻唑基-4-乙酸乙酯 合成 |
| 修稿时间： | 2003-02-16 |
Synthesis of acido 2-formammidotiazol-4-il acetico |
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| Wang Hui,College of Chemistry and Chemical Engineering and Materials Science,Heilongjiang University. Synthesis of acido 2-formammidotiazol-4-il acetico[J]. Heilongjiang Medicine, 2004, 17(4): 285-286 |
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| Authors: | Wang Hui College of Chemistry Chemical Engineering Materials Science Heilongjiang University |
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| Abstract: | Objective:To synthesize acido 2-formammidotiazol-4-il acetico,an intermediate of Cefotiam;Methods-acido 2-formammidotiazol-4-il acetico was synthesized from acido 2-ammidoti- azol-4-il acetico,etil estere by two steps:carbamoyl and hydrolysis.The structure is detected by IR;Resuhs:the total yield is 70%;Conclusion:This method is moderate and the yield is higher, the price is lower and fit for industrial production. |
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| Keywords: | Acido 2-formammidotiazol-4-il acetico Acido 2-ammidotiazol-4-il acetico etil estere synthesis |
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