| 膀胱肿瘤端粒酶活性及其与预后关系的研究 |
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| 引用本文： | 康鸿斌,张亚正,冷江涌,王越先,秦毅强,袁亚光,王云彬,朱小军.膀胱肿瘤端粒酶活性及其与预后关系的研究[J].内蒙古医学杂志,2004,36(3):163-165. |
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| 作者姓名： | 康鸿斌 张亚正 冷江涌 王越先 秦毅强 袁亚光 王云彬 朱小军 |
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| 作者单位： | 1. 内蒙古医学院附属医院泌尿外科、病理科、检验科,内蒙古,呼和浩特,010050
2. 浙江省宁波市第二人民医院泌尿外科,浙江,宁波,315000 |
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| 摘 要： | 目的 :探讨端粒酶活性与膀胱癌组织的临床生物学行为及与预后的关系。方法 :应用银染端粒序列重复扩增 (TRAP)法检测 4 4例膀胱移行细胞癌端粒酶的活性。结果 :4 4例膀胱癌组织中端粒酶表达阳性 39例 (88 5 % )。端粒酶活性阳性表达率与病人的年龄、性别、肿瘤数目、大小、是否有蒂无关 (P >0 0 5 ) ;也与肿瘤的分期、分级无关 (P >0 0 5 )。随访资料表明端粒酶活性与肿瘤病人是否复发无关 (P >0 0 5 )。结论 :端粒酶是膀胱癌理想的肿瘤标记物。膀胱癌端粒酶活性与肿瘤的分级、分期及预后无关。
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| 关 键 词： | 膀胱肿瘤 移行上皮癌 端粒酶 |
| 文章编号： | 1004-0951(2004)03-0163-03 |
Study on Telomerase Activity in Bladder Tumor and Its Relation Ship with Prognosis |
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| KANG Hong-bin,ZHANG Ya-zheng,LENG Jiang-yong,WANG Yue-xian,QIN Yi-qiang,YUAN Ya-guang,WANG Yun-bin,ZHU Xiao-jun.Study on Telomerase Activity in Bladder Tumor and Its Relation Ship with Prognosis[J].Inner Mongolia Medical Journal,2004,36(3):163-165. |
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| Authors: | KANG Hong-bin ZHANG Ya-zheng LENG Jiang-yong WANG Yue-xian QIN Yi-qiang YUAN Ya-guang WANG Yun-bin ZHU Xiao-jun |
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| Institution: | KANG Hong-bin 1,ZHANG Ya-zheng 1,LENG Jiang-yong 2,WANG Yue-xian 1,QIN Yi-qiang 1,YUAN Ya-guang 1,WANG Yun-bin 1,ZHU Xiao-jun 1 |
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| Abstract: | Objective:To investigate the relationship between telomerase activity and clinicobiological action and prognosis of bladder cancer. Method: The telomerase activity was detected in 44 cases of bladder cancer by PCR-based telomerase repeated amplification protocol with silver stain assay (TRAP). Result: The positive expression of telomerase was 88.5%(39/44).Telomerase activity was neither related with the patient's age,sex and the number,Sizeand pedicle of tumor ( P >0.05),nor related with the grade,stage of tumor ( P >0.05).The follow-up data Showed that tolomerase activity was not related with the recurrence of tumor( P>0.05). Conclusions: Telomerase activity is an ideal marker for bladder cancer.Telomerase activity is not related with grade,stage and prognosis of bladder cancer. |
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| Keywords: | Bladder tumor Transitional epithelial cancer Telomerase |
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