24h动态PH监测在支气管哮喘合并胃食管反流病的临床研究

目的探讨24 h动态PH监测在支气管哮喘合并胃食管反流病(GERD)的诊断价值。方法纳入支气管哮喘患者32例(A组),GERD患者40例(B组),支气管哮喘合并GERD患者32例(C组),对3组患者行24 h食管p H监测,记录胃酸反流的总次数,总计、立位、卧位p H4的百分比,并行食管测压。结果C组及B组近段、中段远端的食管体部压力低于A组;A组食管括约肌静息压力、蠕动波传导速度高于C组及B组,反流频数C组低于其他两组;A组酸反流总次数,总计、立位、卧位p H4的百分比和De Meester评分均少于C组及B组。结论 24 h动态PH监测能发现更多的反流时间,卧位p H4百分比及反流频数是重要的参考指标。

Clinical study on 24-hour dynamic monitoring on PH in asthma complicated with gastroesophageal reflux dis-ease

Objective To explore the diagnostic value of 24-hour dynamic monitoring on PH in asthma complicated with gastroesophageal reflux disease ( GERD) .Methods The study selected 32 patients with bronchial asthma as the group A , 40 GERD patients as the group B , and 32 bronchial asthma patients complicated with GERD as the group C .All of them were given 24-hour dynamic monitoring on PH .The total times of gastrointestinal reflux and the percentage of PH <4 by upright or supine position were recorded .Besides, their esophageal pressure was de-termined.Results The esophageal body pressure was lower in the group B and C than in the group A .The esopha-geal sphincter resting pressure and peristaltic wave velocity were higher in the group A than in the group B and C . The regurgitation frequency was lower in the group C than in the other two groups .The total number of acid reflux , the percentage of upright or supine pH <4, and the DeMeester percentage score were less in the group A than in the group C and B .Conclusion 24-h dynamic PH monitoring can find more reflux time , and supine pH<4 percentage and frequency of regurgitation are important reference indexes .