儿童轻症社区获得性肺炎口服抗生素的意向性调查与疗效分析

目的调查分析口服抗生素治疗儿童轻症社区获得性肺炎(CAP)的意向性,并对比口服与静脉给药治疗儿童轻症CAP的临床疗效。方法向138例CAP患儿家长发放调查问卷,调查抗生素不同给药途径的比率及患儿家长用药意愿;入选77例轻症CAP患儿,分为口服抗生素给药组35例和静滴抗生素组42例,比较抗生素口服给药和静脉给药的临床疗效及不良反应。结果 138例轻症CAP患儿家长中54.3%的家长首选静脉给药治疗,87.7%的患儿家长认为静脉给予抗生素治疗比口服给药治疗患儿轻症CAP疗效好。全程口服组与静滴组患儿体温恢复正常时间(2.68±0.58 vs 2.32±0.49)d和肺部啰音消失时间(6.52±1.45vs 5.84±1.17)d差异有统计学意义(P0.05),两组患儿咳嗽明显减轻时间(5.07±1.86 vs 4.68±1.69)d、咳嗽完全消失时间(6.94±1.66 vs 6.29±1.51)d及抗生素疗程(7.80±1.74 vs 7.15±1.46)d,差异无统计学意义(P0.05)。结论家长对抗生素使用存在认识误区可致轻症CAP患儿口服抗生素治疗的意向性较低;口服抗生素与静脉抗生素治疗儿童轻症CAP疗效,无显著性差异。

Intention survey and efficacy analysis on oral antibiotics in the treatment of children with mild community acquired pneumonia ( CAP)

Objective To conduct intention survey on clinical efficacy of oral antibiotics in the treatment of children with mild CAP, and to compare clinical efficacy between oral administration and intravenous administration antibiotics in treating children with mild CAP. Methods 138 mild CAP children were selected to analyze different medication routines and parents' medication intention. 77 mild CAP children were taken as study objects, and they were randomly divided into the oral medication group(35 cases)and the intravenous drip group(42 cases). The clinical efficacy and adverse drug reactions were compared between the two groups. Results 54. 3% parents pre-ferred intravenous drip treatment, and 87. 7% parents considered the efficacy of intravenous drip therapy was super to that of oral medication. There were significant differences in body temperature recovery time(2. 68 ± 0. 58 vs 2. 32 ± 0. 49)d and pulmonary rales sound disappeared time(6. 52 ± 1. 45 vs 5. 84 ± 1. 17)d between the two groups(P<0. 05). There was no significant difference in obvious cough lightening time(5. 07 ± 1. 86 vs 4. 68 ± 1. 69)d, cough disappeared time(6. 94 ± 1. 66 vs 6. 29 ± 1. 51)d and antibiotic treatment regimen(7. 80 ± 1. 74 vs 7. 15 ± 1. 46)d between the two groups(P>0. 05). Conclusion Parents ' misunderstanding on the use of antibiotics can cause lower intention of oral antibiotic in the treatment of mild CAP. The clinical efficacy between oral administered antibi-otics and intravenous drip antibiotics is similar in the treatment of mild CAP.