305例结缔组织病相关间质性肺病临床特点分析

目的分析结缔组织病相关间质性肺病(Connective tissue disease associated interstitial lung disease,CTD-ILD)临床特征。方法回顾性分析305例西京医院临床免疫科CTD-ILD的临床特征及类风湿关节炎间质性肺病(Rheumatoid arthritis associated interstitial lung disease,RA-ILD)和干燥综合征间质性肺病(Sjogren's syndrome associated interstitial lung disease,p SS-ILD)患者胸部高分辨CT特点。结果 CTD患者ILD的发病率为11.78%,其中多发性肌炎相关ILD的发病率最高(53.13%),其次为抗中性粒细胞胞浆抗体相关性血管炎(40.74%)、混合结缔组织病(35.14%)和硬皮病(29.73%)。p SS-ILD和RA-ILD在CTD-ILD中所占比例最大,分别为24.92%和23.61%,两者约占所有CTD-ILD的一半。结论 CTD患者ILD的发病率高,RA-ILD和p SS-ILD是CTD-ILD的主要疾病,加强对CTD-ILD的早期筛查和早期治疗非常重要。

Clinical analysis of 305 patients with connective tissue disease associated interstitial lung disease

Objective To analyze the clinical features of connective tissue disease associated interstitial lung disease (CTD-ILD). Methods The clinical manifestation of 305 patients diagnosed CTD-ILD and chest high resolu-tion computed tomography features of rheumatoid arthritis associated interstitial lung disease ( RA-ILD) and Sjogren's syndrome associated interstitial lung disease ( pSS-ILD) were retrospectively analyzed. Results The total incidence of ILD in CTD was 11. 78%. The highest incidence of ILD was polymyositis ( 53. 13%) , then was anti-neutrophil cytoplasmic antibody associated vasculitis (40. 74%), mixed connective tissue disease (35. 14%) and scleroderma (29. 73%). pSS-ILD and RA-ILD were the major part of the total CTD-ILD with the proportion of 24. 92% and 23. 61% respectively and almost occupied the half of all CTD-ILD patients. Conclusion The incidence of CTD-ILD is very high. pSS-ILD and RA-ILD are the main diseases of CTD-ILD, and the early screening and treatment is very important.