联合检测D-D和FIB对慢阻肺患者肺栓塞风险的预测作用

目的比较D-二聚体(D-D)与纤维蛋白原(FIB)及两者联合检测对慢性阻塞性肺疾病(慢阻肺)急性加重期患者肺栓塞发生风险的预测效能。方法收集安徽省立医院2012年1月至2015年1月诊断为慢阻肺住院患者的一般资料、D-D、FIB等相关数据,比较两种检测方法以及两者联合时的ROC曲线下面积,评估其对肺栓塞风险的预测效能。结果 D-D、FIB联合检测对肺栓塞进行预测时,灵敏度为96.97%,阴性预测值为99.26%,ROC曲线下面积为0.743(95%CI:0.679~0.806),均较单项预测时高,差异均有统计学意义。结论 D-D、FIB联合检测对慢阻肺患者肺栓塞的风险评估有较高的效能。

Predictive value of D-dimer combined with fibrinogen on pulmonary embolism in AECOPD patients

Objective To compare the predictive value of plasma D-dimmer, fibrinogen and the combination of both on pulmonary embolism for hospitalized patients with AECOPD. Methods 669 patients with AECOPD from January 2012 to January 2015 were enrolled in this study. Their demographic data and variables including the D-di-mer and fibrinogen levels were collected and analyzed. The receivers ' operating characteristic curve was applied to compare the predictive value. Results The sensitivity of D-dimer combined with FIB was 96. 97%(P=0. 0001), and the negative predictive value was 99. 26%(P=0. 032). Furthermore, the combined detection presented the lar-gest area under ROC curve(0. 743, 95% CI:0. 679 ~ 0. 806). Conclusion The combined detection of D-dimer and FIB levels has a higher efficiency in predicting pulmonary embolism in AECOPD patients.