氨溴索雾化吸入对恶性肿瘤放射性肺损伤的保护作用

目的观察雾化吸入氨溴索对恶性肿瘤放射性肺损伤的保护作用。方法 106例胸部放疗的患者,随机分为单纯放疗组(对照组)和放疗加氨溴索治疗组(观察组)。观察组放疗第1天给予氨溴索15-30mg雾化吸入,3次/日,连用1个月,对照组给予生理盐水雾化吸入;比较氨溴索雾化吸入对放射性肺损伤的作用。结果放疗结束后1-3个月,观察组的有效率(66.04%、71.70%、77.36%)略高于对照组,但差异均无统计学意义。放疗结束后2、3个月,观察组放射性肺炎发生率(9.43%、18.87%)明显低于对照组(22.64%、33.96%)。放疗结束后6个月,观察组肺CO弥散量下降比对照组少,放射性肺纤维化发生率低于对照组(P0.05)。结论氨溴索雾化吸入对恶性肿瘤放疗患者早期放射性肺炎、晚期肺纤维化均有一定的保护作用。

Protective effect of ambroxol atomization inhalation on radiation-induced pulmonary injury

Objective To observe the protective effect of ambroxol aerosol inhalation on malignant tumor of radiation-induced lung injury. Methods 106 patients who received radiotherapy of chest were randomly divided into the radiotherapy group ( the control group ) and the radiotherapy plus ambroxol treatment group ( the observation group). The observation group received radiotherapy with ambroxol 15-30mg atomization inhalation three times/day for one month, starting on the first day of radiotherapy. The control group received saline inhalation. The effect of at-omizing inhalation of ambroxol hydrochloride on radiation-induced lung injury was compared between the two groups. Results During one to three months after radiotherapy, the effective rate of the observation group ( 66. 04%, 71. 70%, 77. 36%) was slightly higher than that in the control group ( 62. 26%, 69. 81%, 75. 47%) . The inci-dence of radiation pneumonia ( 9. 43%, 18. 87%) in the observation group was significantly lower than that in the control group (22. 64%, 33. 96%) 2 and 3 months after radiotherapy. At the end of 6 months after radiotherapy, the lung CO dispersion in the observation group was significantly lower than that in the control group, and the incidence of radiation-induced pulmonary fibrosis was significantly lower than that of the control group (P<0. 05). Conclusion Ambroxol atomization inhalation has some protective effect on radiation induced early pneuminia and advanced pul-monary fibrosis.