气道黏膜损害程度与迁延和非迁延性支原体肺炎的预后相关性研究

目的探讨气道黏膜损害程度与迁延和非迁延性支原体肺炎的预后相关性。方法对2014年1月~2015年6月在我院就诊的支原体肺炎96例的临床资料进行回顾性分析,其中迁延性支原体肺炎24例,设为迁延组,非迁延性支原体肺炎72例,设为非迁延组。统计分析气道黏膜损害程度与预后的关系及其对纤维支气管镜灌洗次数和肺功能的影响。结果迁延组患者黏膜滤泡样增生、纵行皱褶、黏膜充血肿胀、黏液分泌物增多、黏膜粗糙发生例数与非迁延组比较,P0.05,差异不具有统计学意义;迁延组患者支气管开口炎症性狭窄、黏液栓阻塞、段支气管通气不良发生例数与非迁延组比较,P0.05,差异具有统计学意义;气道黏膜糜烂、肉芽组织增生、管腔闭塞、塑型性支气管炎仅发生于迁延组,与非迁延组比较,P0.05,差异具有统计学意义;迁延组患者经3次或以上纤维支气管镜灌洗例数与非迁延组比较,P0.05,差异具有统计学意义;迁延组患者FVC%、FEV1%、V50%与非迁延组比较,P0.05,差异具有统计学意义。结论迁延性支原体肺炎患者气道黏膜损害程度较重,使用纤维支气管镜灌洗治疗的次数越多,肺功能受损的程度越深。

Correlation study of damage degree of airway mucosa with the prognosis of persistent and non persistent my-coplasma pneumonia

Objective To discuss the correlation of damage degree of airway mucosa with the prognosis of persistent and non persistent mycoplasma pneumonia.Methods The clinical data of 96 patients with mycoplasma pneumonia from January 2014 to June 2015 were retrospectively analyzed,including 24 cases of refractory mycoplas-ma pneumonia as the persistent group and 72 cases of mycoplasma pneumonia as the non-persistent group.The rela-tionship between the degree of airway mucosal damage and the prognosis of airway mucosa and bronchial lavage of fi-ber and pulmonary function were analyzed.Results There was no significant difference in mucosal follicular hyper-plasia,longitudinal folds,mucosal hyperemia,swelling and mucus secretion between the two groups (P >0.05). The incidence of bronchus inflammatory stenosis,mucous plug blocking and segmental bronchi ventilation showed sig-nificant differences between the two groups (P <0.05).Airway mucosal erosion,granulation tissue hyperplasia,lu-minal occlusion,plastic bronchitis occurred only in the persistent group.The cases with three or more than three times fiber bronchial lavage showed significant difference between the two groups (P <0.05).There were statistical significance in FVC%,FEV1 % and V50% between the two groups (P <0.05 ).Conclusion Airway mucosal damage is more severe in persistent mycoplasma pneumonia patients.The more use of bronchial lavage,the deeper lung function damages.