锌指蛋白A20对树突状细胞的免疫调控及其在炎症性肠病发病机制中的作用

泛素化修饰对蛋白质降解及多种细胞功能都具有重要的调控作用,如DNA损伤修复、细胞周期调控、细胞生长、免疫系统功能等。泛素修饰酶锌指蛋白A20被认为是调控机体免疫和炎症反应的重要门户,为NF-κB信号通路中的关键负性调控因子。树突状细胞(DC)是专职的抗原提呈细胞,可以通过多种受体识别炎性反应或病原微生物,是维持机体免疫稳态的关键调节者。近年来,有研究表明,A20在DC功能的调控中发挥着重要作用,可能参与了炎症性肠病的发生和发展。文章基于最新的研究进展,总结A20对DC的免疫调控及其在炎症性肠病发病机制中的作用。

The role of zinc ifnger protein A20 in immune regulation of dendritic cells and in the pathogenesis of inlfammatory bowel disease

Ubiquitin plays a vital role in both protein degradation and many kinds of cellular functions, such as DNA damage repair, cell cycle regulation, cell growth and immune system function.Ubiquitin modiifed enzyme zinc ifnger protein A20 is considered to be an important gateway for the regulation of immune and inlfammatory responses, which is a key negative regulator in NF-κB signaling pathway. Dendritic cell (DC) is a full-time antigen presenting cell that identifies inflammatory response or pathogenic microorganism by multiple receptors, and is a key moderator for immunity homeostasis. Researches in recent years showed that A20 plays an important role in regulating the function of DC, which may take part in the occurrence and development of inlfammatory bowel disease. In this article, the regulation of A20 in the immunoregulation of DC and its function on the pathogenesis of inlfammatory bowel disease were reviewed.