联合检测血管内皮生长因子、血管生成素-2、癌胚抗原对恶性胸腔积液的诊断价值

目的探讨血管内皮生长因子(VEGF)、血管生成素-2(Ang-2)、癌胚抗原(CEA)联合检测对于恶性胸腔积液的诊断价值。方法选取2011年10月至2014年5月于山西大同大学附属医院呼吸内科住院的胸腔积液患者67例。根据确诊结果,分为恶性胸腔积液35例,良性胸腔积液32例。采用酶联免疫吸附试验检测胸腔积液中VEGF、Ang-2、CEA的含量。结果恶性组胸腔积液中VEGF、Ang-2、CEA含量高于良性胸腔积液,差异具有统计学意义(P0.05)。单独检测VEGF、Ang-2、CEA的AUC(ROC曲线下面积)分别是0.844,0.837,0.905,灵敏度74.3%,77.1%,85.7%,特异度87.5%,81.2%,90.6%。联合检测胸腔积液中VEGF、Ang-2、CEA的AUC,灵敏度和特异度分别为0.990,99.2%和100.0%。结论联合检测胸腔积液中的VEGF、Ang-2、CEA对鉴别良、恶性胸腔积液有较好的临床价值。

Diagnostic value of combined detection of VEGF,angiopoietin-2 and CEA in the diagnosis of malignant pleu-ral effusion

Objective To explore the diagnostic value of combined detection of VEGF, angiopoietin-2 and CEA in the diagnosis of malignant pleural effusion. Methods The concentration of VEGF, Ang-2 and CEA in pleu-ral fluid of 67 patients by ELISA, included 35 cases of malignant pleural effusion and 32 cases of benign pleural effu-sion. Results The concentration of VEGF, Ang-2 and CEA was significantly higher in the malignant pleural effusion group than that in the benign pleural effusion group (P<0. 05). The AUC (area under the ROC curve) of VEGF, Ang-2 and CEA separately detected was 0. 844, 0. 837 and 0. 905 respectively. The sensitivity was 74. 3%, 77. 1%and 85. 7% respectively, and the specificity respectively was 87. 5%, 81. 2% and 90. 6%. The sensitivity and spe-cificity of combined detection was 99. 2% and 100% respectively. Conclusion The combined detection of VEGF, Ang-2 and CEA in pleural fluid has important clinical value.