Changes in electroretinogram and serum potassium during l-DOPA treatment in parkinsonism |
| |
Authors: | Dimiter Terziivanov Marie Filipova Ivo Janků Josef Balík Václav Filip Luděk Štika |
| |
Institution: | (1) Department of Clinical Pharmacology, Medical Academy, Sofia Medical School, Sofia, Bulgaria;(2) Department of Neurology, Faculty of Pediatrics, Charles University, V Úvalu 84, 150 00 Prague 5, Motol;(3) Institute of Pharmacology, Czechoslovak Academy of Sciences, Albertov 4, 128 00 Prague;(4) Psychiatric Research Unit, Charles University School of Medicine, Ke Karlovu 11, 128 21 Prague;(5) Department of Neurology, District Institute of National Health, Prague 6, Czechoslovakia |
| |
Abstract: | Summary The relationship of l-DOPA plasma level, parameters of ERG and severity of extrapyramidal symptoms after a single dose of l-DOPA was investigated in 11 patients suffering from parkinsonism of idiopathic or arteriosclerotic origin.After a drug-free night, each patient received his/her usual morning dose of l-DOPA. In the subsequent 3 h, the ERG recordings, blood levels and clinical ratings of extrapyramidal symptoms significantly dropped after a delay of 60 min in relation to the occurrence of the peak plasma l-DOPA level.The initial b wave amplitudes as well as initial serum potassium values were abnormally high. There was a statistically significant correlation between the decrease of b wave amplitude (![Delta](/content/h1n811t426t38622/xxlarge916.gif) b ) and the potassium normalization index (i.e. the ratio between the observed decrease of serum potassium and the pretreatment difference from the middle normal potassium value).A definite interpretation of the data cannot be provided until more knowledge about the origin of b wave of ERG is available. It can be concluded tentatively that dopaminergic processes influence electrophysiological reactivity of the retina. |
| |
Keywords: | Electroretinogram in parkinsonism l- DOPA pharmacokinetics" target="_blank">Dopaminergic control l- DOPA pharmacokinetics Electrolytic balance in parkinsonis |
本文献已被 SpringerLink 等数据库收录! |
|