Radionuclide imaging of epithelial ovarian tumours with 123I-labelled monoclonal antibody (H317) specific for placental-type alkaline phosphatase |
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Authors: | M Critchley S Brownless M Patten P J McLaughlin P M Tromans I W McDicken P M Johnson |
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Affiliation: | 1. Department of Nuclear Medicine, Royal Liverpool Hospital and University of Liverpool, Liverpool, UK;2. Department of Obstetrics and Gynaecology, Royal Liverpool Hospital and University of Liverpool, Liverpool, UK;3. Department of Pathology, Royal Liverpool Hospital and University of Liverpool, Liverpool, UK |
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Abstract: | A murine monoclonal antibody, H317, specific for placental-type alkaline phosphatase was labelled with 123I and assessed as an imaging agent using a gamma camera computer system in 18 patients suspected of possible recurrent or metastatic ovarian cancer 1-4 years after removal of the primary tumour. Four patterns of distribution were visible: (1) normal uptake; (2) focal accumulation; (3) diffuse uptake; and (4) 'cold' areas. Six patients, five of whom were clinically negative for ovarian cancer, had normal scans; 11 patients, eight of whom were clinically positive, had increased uptake. One patient had visibly 'cold' areas. Findings were confirmed, where possible, at surgery. |
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