35961例孕妇产前筛查结果回顾性分析

目的评价妊娠中期孕妇血清(AFP/β-hCG)二联法筛查在唐氏综合征、18-三体综合征和神经管缺陷的临床应用价值。方法对35961例孕14-21周的孕妇采用时间分辨免疫荧光法(DELFLA)进行血清AFP和Free-βHCG浓度的检测,结合孕周、体重、年龄等因素,通过风险评估软件进行风险评估。将筛查结果与B超、羊水、新生儿检查结果对照。结果35961例孕妇中筛查出唐氏综合征高危妊娠1856例,筛查阳性率为5.16%(1856/35961),经羊水染色体核型分析确诊10例唐氏综合征患儿;18-三体高风险者170例,筛查阳性率为0.47%(170/35961),经羊水染色体分析确诊5例;神经管缺陷高危者259例,筛查阳性率为0.72%(259/35961),其中确诊为神经管缺陷胎儿61例。结论通过AFP/β-hCG产前筛查可减少缺陷儿的出生,具有明显的经济效益和社会效益,是落实优生优育政策非常有效的技术手段。

Retrospective analysis of prenatal screening on 35961 cases

Objective：To evaluate the clinic value of the double marker prenatal screening system for Down′s syndrome （DS）,trisomy 18 and neural tube defects （NTD）. Methods： DELFLA double marker reagents are used to test the concentrations of AFP and β-HCG in the serum of 35961 middle period pregnant women whose were pregnant for 14-21 weeks. With factors of children weeks,avoirdupois,age and so on,we evaluated the risk with risk evaluation software. Then compared the results whit type-B ultrasonic ,amniocentesis ,and results of the newborn′s examination. Results： Among the high risk cases of 36951,1856 （5.16%） cases indicate DS and 170 （0.47% ,1856/35961） cases suggest 18-Ⅲ. By amniocentesis,10 cases were diagnosed Down′s syndrome;5 cases were diagnosed 18-Ⅲ;259 （0.72% ,259/35961） examples with neural tube defect high risk were checked.61fetuses with neural tube defect were diagnosed. Conclusion： By the prenatal screening of blood serums AFP /β-hCG,it decreased the rate of birth defects. Prenatal screening has distinct economic and social benefit ,and it is a very effective technic means to carry out our country′s prepotency policy.