| “芩部丹”中三种单体对结核分枝杆菌作用下TLR2表达的影响 |
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| 引用本文： | 王莉新,吴燕燕,王易. “芩部丹”中三种单体对结核分枝杆菌作用下TLR2表达的影响[J]. 中国药理学通报, 2011, 27(9): 1284-1287. DOI: 10.3969/j.issn.1001-1978.2011.09.024 |
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| 作者姓名： | 王莉新 吴燕燕 王易 |
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| 作者单位： | 上海中医药大学免疫学与病原生物学教研室,上海,201203 |
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| 基金项目： | 上海市教委重点学科第五期资助项目 |
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| 摘 要： | 目的观察"芩部丹"中3种单体对巨噬细胞TLR2的调节作用,以探寻其抗结核的可能作用机制。方法取黄芩苷、对叶百部碱、丹参多酚酸盐单体作用于感染结核杆菌的U937单核巨噬细胞,分别采用RT-QPCR、FACS方法检测用药前后巨噬细胞表面TLR2的表达差异。结果与模型组相比,黄芩苷、对叶百部碱、丹参多酚酸盐均具有上调TLR2表达的作用。结论 "芩部丹"中3种单体抗结核作用可能通过纠正TLR2的表达而发挥作用。
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| 关 键 词： | 芩部丹 黄芩苷 对叶百部碱 丹参多酚酸盐 TLR2 结核分枝杆菌 |
Effect of Qibudan on expression of TLR2 in tuberculosis infection |
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| WANG Li-xin,WU Yan-yan,WANG Yi. Effect of Qibudan on expression of TLR2 in tuberculosis infection[J]. Chinese Pharmacological Bulletin, 2011, 27(9): 1284-1287. DOI: 10.3969/j.issn.1001-1978.2011.09.024 |
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| Authors: | WANG Li-xin WU Yan-yan WANG Yi |
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| Affiliation: | WANG Li-xin,WU Yan-yan,WANG Yi(Dept of Immunology and Pathogenic Biology,Shanghai University of TCM,Shanghai 201203,China) |
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| Abstract: | Aim To observe the possible molecular mechanisms of Qibudan against tuberculosis infection.Methods U937 cells infected with H37Ra strain of Mycobacterium were treated with baicalin,tuberostemonine and salvianolate.Then the expression of TLR2 was analysed by Realtime PCR and FACS.Results After infected with H37Ra,the expression of TLR2 in U937 cells was reduced significantly in mRNA level.Similar result was obtained in the protein expression of TLR2.When added baicalin,tuberostemonine and salvianolate,the mR... |
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| Keywords: | TLR2 |
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