Guanylate-binding proteins: niche recruiters for antimicrobial effectors |
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| Authors: | Christopher D Dupont Christopher A Hunter |
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| Affiliation: | Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 380 South University Avenue, Philadelphia,?PA?19104, USA. |
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| Abstract: | There are fundamental questions regarding how IFN-γ activates host cells to eliminate intracellular pathogens. In this issue of Immunity, Yamamoto et?al. (2012) demonstrate a critical role for the p65 guanylate-binding proteins (GBPs) in this process during infection with Toxoplasma gondii. |
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