Présent et futur de la thérapie cellulaire des brûlures |
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Authors: | L. Bargues M. PratT. Leclerc E. BeyJ.-J. Lataillade |
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Affiliation: | a Centre de traitement des brûlés, hôpital d’instruction des armées Percy, 101, avenue Henri-Barbusse, 92141 Clamart, France b Service de chirurgie plastique, hôpital d’instruction des armées Percy, 101, avenue Henri-Barbusse, 92141 Clamart, France c Département recherches et thérapies cellulaires, centre de transfusion sanguine des armées, BP 410, 92141 Clamart, France |
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Abstract: | Severe burned patients need definitive and efficient wound coverage. Outcome of massive burns has been improved by using cultured epithelial autografts (CEA). Despite fragility, percentages of success take, cost of treatment and long-term tendency to contracture, this surgical technique has been developed in few burn centres. First improvements were to combine CEA and dermis-like substitute. Cultured skin substitutes provide earlier skin closure and satisfying functional result. These methods have been used successfully in massive burns. Second improvement was to allow skin regeneration by using epidermal stem cells. Stem cells have capacity to differentiate into keratinocytes, to promote wound repair and to regenerate skin appendages. Human mesenchymal stem cells contribute to wound healing and were evaluated in cutaneous radiation syndrome. Skin regeneration and tissue engineering methods remain a complex challenge and offer the possibility of new treatment for injured and burned patients. |
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Keywords: | Brû lure Culture é pithé lium autologue Cellules souches Gé nie tissulaire |
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