Coeliac disease characteristics, compliance to a gluten free diet and risk of lymphoma by subtype |
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Authors: | Ola Olé n,Johan Askling,Jonas F. Ludvigsson,Hans Hildebrand,Anders Ekbom,Karin Ekströ m Smedby |
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Affiliation: | aSachs’ Children's Hospital, Stockholm South General Hospital, Sweden;bClinical Epidemiology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden;cRheumatology Unit, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden;dPediatric Department, Örebro University Hospital, Sweden;eDepartment of Women and Child Health, Astrid Lindgren Children's Hospital, Stockholm, Sweden;fDepartment of Oncology-Pathology, Karolinska Institutet, Cancer Center Karolinska, Karolinska University Hospital Solna, Stockholm, Sweden |
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Abstract: | ObjectiveCoeliac disease is associated with an increased risk of malignant lymphomas. We investigated the importance of coeliac disease characteristics and diet compliance for risk of lymphoma.MethodsIn a nested case–control design, we identified 59 patients with lymphoma and 137 matched controls from a population-based cohort of 11,650 inpatients with coeliac disease. We assessed coeliac disease characteristics at diagnosis and dietary compliance collected prospectively from medical records during follow-up.ResultsPoor compliance was not significantly associated with risk of lymphoma overall (odds ratio 1.83, 95% confidence interval 0.78–4.31) nor of lymphoma subtypes. Risk estimates differed by subtype; risk of T-cell lymphoma (odds ratio 1.01, confidence interval 0.32–3.15) or intestinal lymphoma (odds ratio 0.66, confidence interval 0.17–2.56) was unelevated, whereas there was an indication of a risk increase of B-cell lymphoma (odds ratio 4.74, confidence interval 0.89–25.3) or extraintestinal lymphoma (odds ratio 3.00, confidence interval 0.73–12.3) following poor compliance. History of weight loss (odds ratio 2.89, confidence interval 1.00–8.29) at coeliac disease diagnosis was associated with an increased risk of lymphoma when excluding tumours occurring with short latency (<3 years).ConclusionsCompliance to a gluten-free diet did not significantly alter lymphoma risk, but a moderate effect cannot be excluded. Weight loss, a potential marker of coeliac disease severity, may be associated with lymphoma risk. |
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Keywords: | Abbreviations: CD, coeliac disease CI, confidence interval ETTL, Enteropathy-Type T-cell Lymphomas GFD, gluten free diet HR, hazard ratio OR, odds ratio |
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